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Overview

Uniprot ID	A0A5G2R762
Protein Name	Cleavage stimulation factor subunit 3
Gene Name	CSTF3
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
102	YVRETKGKLPSYKEK
426	KIFELGLKKYGDIPE

Function

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs

Protein Sequence

10 SLFSFPSQAA 20 EYVPEKVKKA 30 EKKLEENPYD 40 LDAWSILIRE 50 AQNQPIDKAR 60 KTYERLVAQF 70 PSSGRFWKLY 80 IEAELFQRCL 90 MKVLHIDLWK 100 CYLSYVRETK 110 GKLPSYKEKM 120 AQAYDFALDK 130 IGMEIMSYQI 140 WVDYINFLKG 150 VEAVGSYAEN 160 QRITAVRRVY 170 QRGCVNPMIN 180 IEQLWRDYNK 190 YEEGINIHLA 200 KKMIEDRSRD 210 YMNARRVAKE 220 YETVMKGLDR 230 NAPSVPPQNT 240 PQEAQQVDMW 250 KKYIQWEKSN 260 PLRTEDQTLI 270 TKRVMFAYEQ 280 CLLVLGHHPD 290 IWYEAAQYLE 300 QSSKLLAEKG 310 DMNNAKLFSD 320 EAANIYERAI 330 STLLKKNMLL 340 YFAYADYEES 350 RMKYEKVHSI 360 YNRLLAIEDI 370 DPTLVYIQYM 380 KFARRAEGIK 390 SGRMIFKKAR 400 EDTRTRHHVY 410 VTAALMEYYC 420 SKDKSVAFKI 430 FELGLKKYGD 440 IPEYVLAYID 450 YLSHLNEDNN 460 TRVLFERVLT 470 SGSLPPEKSG 480 EIWARFLAFE 490 SNIGDLASIL 500 KVEKRRFTAF 510 KEEYEGKETA 520 LLVDRYKFMD 530 LYPCSASELK 540 ALGYKDVSRA 550 KLAAIIPDPV 560 VAPSIVPVLK 570 DEVDRKPEYP 580 KPDTQQMIPF 590 QPRHLAPPGL 600 HPVPGGVFPV 610 PPAAVGPFVQ 620 VDELMEIFRR 630 CKIPNTVEEA 640 VRIITGGAPE 650 LAVEGNGPVE 660 SNAVLTKAVK 670 RPNEDSDEDE 680 EKGAVVPPVH 690 DIYRARQQKR IR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Biological Process	GO:0031124	mRNA 3'-end processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.