Search Results
Overview
| Uniprot ID | A0A5G2R787 |
|---|---|
| Protein Name | Prenylcysteine oxidase 1 |
| Gene Name | PCYOX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 259 | WAVKGGNKLVCSRLL |
| 288 | IEEKTRTKQTGNPTK |
| 66 | QKFGKDVKIDVFEKG |
| 72 | VKIDVFEKGEVGGRL |
Function
Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides. Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded
Protein Sequence
10
MKPLAGGLPC
20
FLTFGLWLGL
30
LLLCSWGCPG
40
SAAPRSPPEK
50
IAVIGAGIGG
60
TSAAYYLRQK
70
FGKDVKIDVF
80
EKGEVGGRLA
90
TLTMQGQEYE
100
SGGSIIHPLN
110
LHMKRFVKDL
120
GLSAVQSPSG
130
LVGVYNGETL
140
VYEESSWFII
150
NMIKLIWYYG
160
FQSLRMHMWV
170
EDILDKFMRI
180
YRYQSHDYAF
190
SSVEKLLHSL
200
GGDDFLGLFN
210
RSLLETLQKA
220
GFSEKFLDEI
230
ITPVMRVNYG
240
QTMNINGFVG
250
AVSMSCTDPG
260
LWAVKGGNKL
270
VCSRLLQASK
280
SNLISGSVMS
290
IEEKTRTKQT
300
GNPTKVYEVV
310
YQTGPEIHSD
320
FYDIVLVATP
330
LNQKMSNITF
340
LNFDPPIEEF
350
HQYYEPLVTT
360
LIKGQLNSTV
370
FSSRALDEFD
380
LGTILTTDNP
390
DLFINSIGLV
400
SSVEENNNPQ
410
PKVERAHVWK
420
VFSAGPLTKE
430
QILKLFVSYD
440
YAVKQSWLAY
450
PHYTPPEKCP
460
STILHDQLYY
470
LNGIEFAASA
480
MEMSAVAGYN
490
AALLAYHRWK
IRT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005764 | lysosome |
| Molecular Function | GO:0001735 | prenylcysteine oxidase activity |
| Biological Process | GO:0030328 | prenylcysteine catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.