Overview
| Uniprot ID | A0A5G2R7E5 |
|---|
| Protein Name | Protein SEC13 homolog |
|---|
| Gene Name | SEC13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 174 |
QKPNYIKKFASGGCD |
| 31 |
CSSDRSVKIFDVRNG |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
GRVVGVVLNH
20
DAQMDYYGTR
30
LATCSSDRSV
40
KIFDVRNGGQ
50
ILIADLRGHE
60
GPVWQVAWAH
70
PMYGNILASC
80
SYDRKVIIWK
90
EENGTWEKTH
100
EHTGHDSSVN
110
SVCWAPHDYG
120
LILACGSSDG
130
AISLLTYTGL
140
GQWEVKKINN
150
AHTIGCNAVS
160
WAPAVVPGSL
170
IDQPSGQKPN
180
YIKKFASGGC
190
DNLIKLWKEE
200
EDGQWKEEQK
210
LEAHSDWVRD
220
VAWAPSIGLP
230
TSTIASCSQD
240
GRVFIWTCDD
250
ASGNTWSPKL
260
LHKFNDVVWH
270
VSWSITANIL
280
AVSGGDNKVT
290
LWKESVDGQW
300
VCISDVNKGQ
310
GSVSTSITEG
QQNEQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.