Search Results

Overview

Uniprot IDA0A5G2R7W5
Protein NameTripeptidyl-peptidase 2
Gene NameTPP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1060 RGLKFATKLVEEKPT
1065 ATKLVEEKPTKENWK
1068 LVEEKPTKENWKNCI

Function

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis

Protein Sequence

10 MFLSLFKGTQ 20 LSNIKVCSNC 30 QANKLIKEEL 40 QSQVELLNSF 50 EKKYSDPGPV 60 YDCLVWHDGE 70 TWRACIDSNE 80 DGDLSKSTVL 90 RNYKEAQEYG 100 SFGTAEMLNY 110 SVNIYDEGNL 120 LSIVTSGGAH 130 GTHVASIAAG 140 HFPEEPERNG 150 VAPGAQILSI 160 KIGDTRLSTM 170 ETGTGLIRAM 180 IEVINHKCDL 190 VNYSYGEATH 200 WPNSGRICEV 210 ISEAVWKHNI 220 IYVSSAGNNG 230 PCLSTVGCPG 240 GTTSSVIGVG 250 AYVSPDMMVA 260 EYSLREKLPA 270 NQYTWSSRGP 280 SADGALGVSI 290 SAPGGAIASV 300 PNWTLRGTQL 310 MNGTSMSSPN 320 ACGGIALILS 330 GLKANNADYT 340 VHSVRRALEN 350 TAVKADNIEV 360 FAQGHGIIQV 370 DKAYDYLVQN 380 TSFANKLGFT 390 VTVGNNRGIY 400 LRDPIQVAAP 410 SDHGVGIEPV 420 FPENTENSEK 430 ISLQLHLALT 440 SNSSWVQCPS 450 HLELMNQCRH 460 INIRVDPRGL 470 REGLHYTEVC 480 GYDTASPNAG 490 PLFRVPITAV 500 IAAKVNESSH 510 YDLAFTDVHF 520 KPGQIRRHFI 530 EVPEGATWAE 540 VTVCSCSSEV 550 SAKFVLHAVQ 560 LVKQRAYRSH 570 EFYKFCSLPE 580 KGTLTEAFPV 590 LGGKAIEFCI 600 ARWWASLSDV 610 NIDYTISFHG 620 IVCTAPQLNI 630 HASEGINRFD 640 VQSSLKYEDL 650 APCITLKSWV 660 QTLRPLSAKT 670 KPLGSRDVLP 680 NNRQLYEMIL 690 TYNFHQPKSG 700 EVTPSCPLLC 710 ELLYESEFDS 720 QLWIIFDQNK 730 RQMGSGDAYP 740 HQYSLKLEKG 750 DYTIRLQIRH 760 EQISDLERLK 770 DLPFIVSHRL 780 SNTLSLDIHE 790 NHSLALLGKK 800 KSSNLTLPPK 810 YNQPFFVTSL 820 PDDKIPKGAG 830 PGCYLSGSLT 840 LSKTELGKKA 850 DVIPVHYYLI 860 SPPTKTKNGS 870 KDKDKDSEKE 880 KDLKEEFTEA 890 LRDLKIQWMT 900 KLDSSDIYNE 910 LKETYPNYLP 920 LYVARLHQLD 930 AEKERMKRLN 940 EIVEAANAVI 950 SHIDQTALAV 960 YIAMKTDPRP 970 DAAIIKNDMD 980 KQKSTLVDAL 990 CRKGCALADH 1000 LLQAQEQEGA 1010 VSSDAEGREE 1020 EGEGTLDSLT 1030 ETFWETTKWT 1040 DLFDSKVLTF 1050 AYKHALVNKM 1060 YGRGLKFATK 1070 LVEEKPTKEN 1080 WKNCIQLMKL 1090 LGWTHCASFT 1100 ENWLPIMYPP DYCVF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004177 aminopeptidase activity
Molecular Function GO:0004252 serine-type endopeptidase activity
Molecular Function GO:0008240 tripeptidyl-peptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.