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Overview

Uniprot IDA0A5G2R7X3
Protein NameEukaryotic translation initiation factor 3 subunit L
Gene NameEIF3L
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
109 YRCKTAKKSEEEIDF
203 LENIELNKKSMYSRV
396 RIQLLVFKHKMKNLV
451 FFIRQIHKFEELNRT

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression

Protein Sequence

10 MNYRPVACPA 20 MSLTKRCMRS 30 RTSMRTDAVF 40 LILYKELYYR 50 HIYAKVSGGP 60 SLEQRFESYY 70 NYCNLFNYIL 80 NADGPAPLEL 90 PNQWLWDIID 100 EFIYQFQSFS 110 QYRCKTAKKS 120 EEEIDFLRSN 130 PKIWNVHSVL 140 NVLHSLVDKS 150 NINRQLEVYT 160 SGGDPESVAG 170 EYGRHSLYKM 180 LGYFSLVGLL 190 RLHSLLGDYY 200 QAIKVLENIE 210 LNKKSMYSRV 220 PECQVTTYYY 230 VGFAYLMMRR 240 YQDAIRVFAN 250 ILLYIQRTKS 260 MFQRTTYKYE 270 MINKQNEQMH 280 ALLAIALTMY 290 PMRIDESIHL 300 QLREKYGDKM 310 LRMQKGDPQV 320 YEELFSYSCP 330 KFLSPVVPNY 340 DNVHPNYHKE 350 PFLQQLKVFS 360 DEVQQQAQLS 370 TIRSFLKLYT 380 TMPVAKLAGF 390 LDLTEQEFRI 400 QLLVFKHKMK 410 NLVWTSGISA 420 LDGEFQSASE 430 VDFYIDKDMI 440 HIADTKVARR 450 YGDFFIRQIH 460 KFEELNRTLK KMGQRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016282 eukaryotic 43S preinitiation complex
Cellular Component GO:0033290 eukaryotic 48S preinitiation complex
Cellular Component GO:0005852 eukaryotic translation initiation factor 3 complex
Molecular Function GO:0003743 translation initiation factor activity
Biological Process GO:0001732 formation of cytoplasmic translation initiation complex

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.