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Overview

Uniprot ID	A0A5G2R894
Protein Name	Mitochondrial import inner membrane translocase subunit TIM44
Gene Name	TIMM44
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
123	TGEVIRKKLGEITGT
159	EEAAKTAKQSAESVS

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source

Protein Sequence

10 MAAAALRGGW 20 CRCPRRCFSS 30 GVHFLSRHNL 40 VPLPLGTYQM 50 PWPSGQQTLS 60 RSYSSGNRKG 70 FLSGLLDNIK 80 QELAKNKEMK 90 ESIKKFRDEA 100 RKLEESDALQ 110 EARRKYRTIE 120 SETMRTGEVI 130 RKKLGEITGT 140 VKESLDEVSK 150 SDLGRKIKEG 160 VEEAAKTAKQ 170 SAESVSKGGE 180 KLGRTAAFKA 190 LSQGVESVKK 200 EIDESVLGQT 210 GPYRRPERLR 220 KRKEFAGEKF 230 KEEKVFEANE 240 EALGVVLHKD 250 SKWYQQWKDF 260 RDNNVVFNRF 270 FEMKMKYDES 280 DNALIRASRV 290 LTDKVTDLLG 300 GLFSKTEMSE 310 VLTEILRVDP 320 AFDKERFLQQ 330 CENDIIPNVL 340 EAMISGELDI 350 LKDWCYEATY 360 SQLAHPIQQA 370 KALGLQFHSR 380 ILDIDNIDLA 390 MGKMMEQGPV 400 LIITFQAQLV 410 MVIKNPKGEV 420 VEGDPVSKAG 430 REGRRQEQPD 440 GSLWPPCTDS 450 RSESGFCDSL 460 GMAGWHLEKS 470 QGPSWTWWRL EGG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex
Molecular Function	GO:0005524	ATP binding
Biological Process	GO:0015031	protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.