Search Results

Overview

Uniprot IDA0A5G2R8E1
Protein NameProtein phosphatase 1 regulatory subunit
Gene NamePPP1R12A
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
197 INDVRHAKSGGTALH
209 ALHVAAAKGYTEVLK
320 SQKTFKNKETLIIEP
532 SSSYTRRKWEDDLKK
539 KWEDDLKKNSSINEG

Function

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity

Protein Sequence

10 MKMADAKQKR 20 NEQLKRWIGS 30 ETDLEPPVVK 40 RQKTKVKFDD 50 GAVFLAACSS 60 GDTDEVLKLL 70 HRGADINYAN 80 VDGLTALHQA 90 CIDDNVDMVK 100 FLVENGANIN 110 QPDNEGWIPL 120 HAAASCGYLD 130 IAEFLIGQGA 140 HVGAVNSEGD 150 TPLDIAEEEA 160 MEELLQNEVN 170 RQGVDIEAAR 180 KEEERIMLRD 190 ARQWLNSGHI 200 NDVRHAKSGG 210 TALHVAAAKG 220 YTEVLKLLIQ 230 AGYDVNIKDY 240 DGWTPLHAAA 250 HWGKEEACRI 260 LVDNLCDMEM 270 VNKVGQTAFD 280 VADEDILGYL 290 EELQKKQNLL 300 HSEKREKKSP 310 LIESTANMDN 320 NQSQKTFKNK 330 ETLIIEPEKN 340 ASRIESLEQE 350 KVDDEEEGKK 360 DESSCSSEED 370 EEDDSESEAE 380 TDKTKPMAPV 390 TNANTSSTQA 400 APVAVTTPTL 410 SSGQATPTSP 420 IKKFPTPATK 430 ISPKEEERKD 440 ESPASWRLGL 450 RKTGSYGALA 460 EITASKEAQK 470 EKDTAGVIRS 480 ASSPRLSSSL 490 DNKEKEKDNK 500 GTRLAYVAPT 510 IPRRLASTSD 520 MEEKENRDSL 530 GLRTSSSYTR 540 RKWEDDLKKN 550 SSINEGSTYQ 560 KSCSFGRRQD 570 DLISSSVPST 580 TSTPTVTSAA 590 GLQKGLLSST 600 STTTKITTGS 610 SSAGTQSSTS 620 NRVWAEDSTE 630 KDKDSVPTAL 640 TVPVAPAVVN 650 AAAATTTLTT 660 TTAGTVSSTS 670 EVRERRRSYL 680 TPVRDEESES 690 QRKARSRQGV 700 TLTDLQEAEK 710 TIGRSRSTRT 720 REQENEEKEK 730 EEKEKQDKEK 740 QEEKKESETS 750 REDEYKQKYS 760 RTFDETYQRY 770 RPASTSGSAT 780 PSSSLSTMSS 790 SLYASSQLNR 800 PNSLVGITSA 810 YSRGSTKENE 820 REGEKREEEK 830 EGEDKSQPKS 840 IRERRRPREK 850 RRSTGVSFWT 860 QDSDENEQEQ 870 QSDTEEGSSK 880 KETQVNTVFK 890 GYETSSTSAS 900 DRYDSLLGRS 910 GSYSYLEERK 920 PYSSRLEKDD 930 STDFKKLYEQ 940 ILAENEKLKA 950 QLHDTNMELT 960 DLKLHWRRPP 970 RQERFADRSL 980 LEMEKRVSML 990 PDLKADNQRL 1000 KDENGALIRV ISKLSK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031672 A band
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0072357 PTW/PP1 phosphatase complex
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0071889 14-3-3 protein binding
Molecular Function GO:0004857 enzyme inhibitor activity
Molecular Function GO:0017020 myosin phosphatase regulator activity
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0007098 centrosome cycle
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0007165 signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.