Overview
| Uniprot ID | A0A5G2R8H4 |
|---|
| Protein Name | - |
|---|
| Gene Name | CNOT3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 105 |
TKTKAYSKEGLGLAQ |
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity
Protein Sequence
10
MADKRKLQGE
20
IDRCLKKVSE
30
GVEQFEDIWQ
40
KLHNAANANQ
50
KEKYEADLKK
60
EIKKLQRLRD
70
QIKTWVASNE
80
IKDKRQLIDN
90
RKLIETQMER
100
FKVVERETKT
110
KAYSKEGLGL
120
AQKVDPAQKE
130
KEEVGQWLTN
140
TIDTLNMQVD
150
QFESEVESLS
160
VQTRKKKGDK
170
DKQDRIEGLK
180
RHIEKHRYHV
190
RMLETILRML
200
DNDSILVDAI
210
RKIKDDVEYY
220
VDSSQDPDFE
230
ENEFLYDDLD
240
LEDIPQALVA
250
TSPPSHSHME
260
DEIFNQSSST
270
PTSTTSSSPI
280
PPSPANCTTE
290
NSEDDKKRGR
300
STDSEVSQSP
310
AKNGSKPVHS
320
NQHPQSPAVP
330
PSYPSGPPPT
340
ASALSTTPGN
350
NGAPAPAAPA
360
SALGPKASPA
370
PSHNSGTPAP
380
YAQAVAPPAP
390
SGPSTAQPRP
400
PSVQPGGGGG
410
GGSGGGGGGG
420
SSNNSSGGGG
430
AGKQNGATSY
440
SSVVADSPAE
450
VALSSSGGNT
460
TSSQALGPPS
470
GPHNPPPSTS
480
KEPSAAAPTG
490
AGGVAPGSGN
500
NSGGPSLLVP
510
LPVNPPSSPT
520
PSFSEAKAAS
530
TLLNGPPQFS
540
AAPEIKAPEP
550
LSSLKSMAER
560
AAISSGIEDP
570
VPTLHLTERD
580
IILSSTSAPP
590
ASAQPPLQLS
600
EVNIPLSLGV
610
CPLGPVPLTK
620
EQLYQQAMEE
630
AAWHHMPHPS
DSERIR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030015 |
CCR4-NOT core complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000932 |
P-body |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0006417 |
regulation of translation |
| Biological Process |
GO:0031047 |
regulatory ncRNA-mediated gene silencing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.