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Overview

Uniprot IDA0A5G2R8H5
Protein NameAP-3 complex subunit delta-1
Gene NameAP3D1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
176 IMYKVFLKYPESLRP

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Protein Sequence

10 MALKMVKGSI 20 DRMFDKNLQD 30 LVRGIRNHKE 40 DEAKYISQCI 50 DEIKQELKQD 60 NIAVKANAVC 70 KLTYLQMLGY 80 DISWAAFNII 90 EVMSASKFTF 100 KRIGYLAASQ 110 CFHEGTDVIM 120 LTTNQIRKDL 130 SSPSQYDTGV 140 ALTGLSCFVT 150 PDLARDLAND 160 IMTLMSHTKP 170 YIRKKAVLIM 180 YKVFLKYPES 190 LRPAFPRLKE 200 KLEDPDPGVQ 210 SAAVNVICEL 220 ARRNPKNYLS 230 LAPLFFKLMT 240 SSTNNWVLIK 250 IIKLFGALTP 260 LEPRLGKKLI 270 EPLTNLIHST 280 SAMSLLYECV 290 NTVIAVLISL 300 SSGMPNHSAS 310 IQLCVQKLRI 320 LIEDSDQNLK 330 YLGLLAMSKI 340 LRTHPKSVQA 350 HKDLVLQCLD 360 DKDESIRLRA 370 LDVSKKNLME 380 IVKKLMTHVD 390 KAEGTTYRDE 400 LLTKIIDICS 410 QSNYQHITNF 420 EWYISILVEL 430 TRLEGTRHGH 440 LIAAQMLDVA 450 IRVKAIRRFA 460 VSQMSALLDS 470 AHLVASSTQR 480 NGICEVLYAA 490 AWICGEFSEH 500 LQDPQQTLEA 510 MLRPKVTTLP 520 GHIQAVYVQN 530 VVKLYAAILQ 540 QKEQAADAQA 550 AQEVTQLLVE 560 RLPQFVQSAD 570 LEVQERASCI 580 LQLVKHVQKL 590 QAKDMPVAEE 600 VSALFAGELN 610 PVAPKAQKKV 620 PVPEGLDLDA 630 WINEPLSDSE 640 SEDEKPKAIF 650 QDEEQRHAKQ 660 RPPEADEQEL 670 ARRREARKQE 680 QANNPFYIKS 690 SPSPQKRYQD 700 APGVDHIPVV 710 QIDLSVPLKV 720 PGMPMSDQYV 730 KLEEERRHQQ 740 RLEKDKRKKK 750 RRERERRGTR 760 RHSSLHTESD 770 EDIAPAQRVD 780 IVTEEMPENA 790 LPSDEDDKDP 800 NDPYRALDID 810 LDKPLADSEK 820 LPVQKHRNAE 830 TPKSPEKEDI 840 PVIEKKSKKP 850 KKKEKKHKEK 860 EREKKKKRKE 870 AEKKTSKEKK 880 KKHKKDKEER 890 PKDKKKSKKK 900 TPPREGVAEP 910 VENGALDEEP 920 LPPMSSYCLL 930 AENSYIKMTY 940 DVQGSLQKDS 950 QVTVSVVLEN 960 QSSSFLKSME 970 LNVLDSLNAR 980 LARPEGSSVH 990 DGVPVPFQLP 1000 PGISNEAQFV 1010 FTIQSIVMAQ 1020 KLKGTLSFIA 1030 KNDEGSTHEK 1040 LDFKLHFTCT 1050 SYLVTTPCYS 1060 DAFAKLLESG 1070 DLSMSSIKVD 1080 GISMSFQNLL 1090 AKICFHHRFS 1100 VVERVDSCAS 1110 MYSRSIQGHH 1120 VCLLVKKGEK 1130 SVSVDGKCSD 1140 PTLLSNLLEE MKETLAKC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030123 AP-3 adaptor complex
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0000139 Golgi membrane
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0007041 lysosomal transport
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.