Search Results
Overview
| Uniprot ID | A0A5G2R8M4 |
|---|---|
| Protein Name | Filamin-binding LIM protein 1 |
| Gene Name | FBLIM1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 145 | CYQDTLEKCGKCGEG |
| 148 | DTLEKCGKCGEGVRE |
| 201 | CLDDFYRKFAPVCSI |
| 264 | LNNRLFCKPCHVKRS |
| 50 | RESPVPVKAPGAGSA |
Function
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion
Protein Sequence
10
MASKPEKRVA
20
SSVFITLAPP
30
RRDEAVVEEV
40
KRAACEARPG
50
CPRESPVPVK
60
APGAGSAGRL
70
RSWAPPGRAS
80
APVPAVPPQL
90
SNGDICAFCH
100
KTVSPRELAV
110
EAMKRQYHAQ
120
CFTCRVCRRQ
130
LAGQSFYQKD
140
GRPLCEPCYQ
150
DTLEKCGKCG
160
EGVREHIIRA
170
LGQAFHPTCF
180
TCVTCARCIG
190
DESFALDSQN
200
EVYCLDDFYR
210
KFAPVCSICE
220
NPIIPRDGKD
230
AFKIECMGRN
240
FHENCYRCED
250
CRILLSVEPT
260
DQGCYPLNNR
270
LFCKPCHVKR
SAASCC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0008360 | regulation of cell shape |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.