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Overview

Uniprot IDA0A5G2R957
Protein NameIntegrin alpha-5
Gene NameITGA5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
847 SSGPQILKCPEAECF
880 LHFRVWAKTFLQREH

Function

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling

Protein Sequence

10 MGSRTPGSPL 20 QAVQLRWGPR 30 RRSRLLPLLP 40 PPLLLLLLLP 50 PPLRVGGFNL 60 DAEAPAVLSG 70 PPGSFFGFSV 80 EFYRPGTDGV 90 SVLVGAPKAN 100 TSQPGVLQGG 110 AVYLCPWATS 120 PAPCTPIEFD 130 SKGSRILESS 140 PSSLEGDEPV 150 EYKSLQWFGA 160 TVRAHGSSIL 170 ACAPLYSWRT 180 EKEPLNDPVG 190 TCYLSTDNFT 200 RILEYAPCRS 210 DFSSAAGQGY 220 CQGGFSAEFT 230 KTGRVVLGGP 240 GSYFWQGQIL 250 SATQEQISES 260 YYPEYLINPV 270 QGQLQTRQAS 280 SIYDDSYLGE 290 LPGLGNFVAG 300 VPKGNLTYGY 310 VTILNGSDIR 320 SLYNFSGEQM 330 ASYFGYAVAA 340 TDINGDGLDD 350 LLVGAPLLME 360 RTADGRPQEV 370 GRVYIYLQSP 380 AGMEPAPART 390 LTGHDEFGRF 400 GSSLTPLGDL 410 DQDGYNDVAI 420 GATFGGENRQ 430 GAVFIFPGGP 440 EGLASKPSQV 450 LQPLWAAGHT 460 PDFFGSALRG 470 GRDLDGNGYP 480 DLIVGSFGVD 490 KAVVYRGRPI 500 VSASASLSIF 510 PAMFNPEERS 520 CNLEGNPDCR 530 EMKIYLRNES 540 EFRDKLSPIH 550 IALNFSLDPQ 560 APVDSHGLRP 570 VLHYQSKSRI 580 EDKAQILLDC 590 GEDNICVPDL 600 QLEVFGDQNH 610 VYLGDKNSLN 620 LTFHAQNVGE 630 GGAYEAELRV 640 TAPPEAEYSG 650 LVRHPGNFSS 660 LSCDYFAVNQ 670 SRLLVCDLGN 680 PMKAGASLWS 690 GLRFTVPHLR 700 DTKKTIQFDF 710 QILSKNLNNS 720 QSEVVSFRLS 730 VEAQAQVSLN 740 GVSKPEAVIF 750 PVSDWHPRDP 760 PQEEEDVGPA 770 VHHVYELINL 780 GPSSISRGVL 790 ELSCPQALEG 800 RQLLYVTRVT 810 GLSNCTTSHP 820 LNPQGLELDP 830 ESPQHHRLQR 840 RDAASRSPAS 850 SGPQILKCPE 860 AECFRLRCEL 870 GPLHRQESRS 880 LQLHFRVWAK 890 TFLQREHQPF 900 SLQCEAVYQA 910 LKMPYRILPR 920 QLPQKELQVA 930 TAVQWIKAEG 940 SHGVPLWIII 950 LAILVGLLLL 960 GLLIYILYKL 970 GFFKRSLPYG 980 TAMEKAQLKP PATSDA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030054 cell junction
Cellular Component GO:0009986 cell surface
Cellular Component GO:0008305 integrin complex
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0045765 regulation of angiogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.