Search Results

Overview

Uniprot IDA0A5G2R962
Protein NameHeat shock protein 75 kDa, mitochondrial
Gene NameTRAP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
317 YVAQAPDKPRYTLHY
362 SVSLYSRKVLIQTKA
406 QESALIRKLQGVLQQ
550 GSRVTNVKVTLRLDT
651 RLNRLLIKALERQPP
89 EFQAETKKLLDIVAR

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Protein Sequence

10 TFTLKNLDPF 20 WGPVFPVRGA 30 GNSVLCPRRP 40 PAQSWHPRQC 50 LASSFHAGRP 60 FSSQAAEDRK 70 EEPPHCIISS 80 SETVQGSVSK 90 HEFQAETKKL 100 LDIVARSLYS 110 EKEVFIRELI 120 SNASDALEKL 130 RHKLVSEGQT 140 LPEMEIHLQT 150 DSEKGTITIQ 160 DTGVGMTREE 170 LVSNLGTIAR 180 SGSKAFLDAL 190 QNQAEASGKI 200 IGQFGVGFYS 210 AFMVADKVEV 220 YSRSVDAGSP 230 GFQWLSDGSG 240 VFEIAEAAGV 250 RTGTKIIIHL 260 KADSREFAHE 270 ARVRDVVTKY 280 SNFVSFPLYL 290 NGRRLNTLQA 300 VWMMDPKDVS 310 EEQHEEFYRY 320 VAQAPDKPRY 330 TLHYKTDAPL 340 NIRSIFYVPE 350 MKPSVFDVSR 360 ELGPSVSLYS 370 RKVLIQTKAT 380 NILPTWLRFV 390 RGVVDSEDIP 400 LNLSRELLQE 410 SALIRKLQGV 420 LQQRLIKFFS 430 DQSKKDVEKY 440 ARFFEDYGLF 450 MREGIVTTTE 460 QEVKVGSGLL 470 GCLRLPDGSD 480 LGPSQVLFCY 490 EQFDELTLLH 500 LREFDRKKLI 510 SVETDIVIDH 520 YKEEKFEDSS 530 PAGDRLSEEE 540 MEDLMAWMRN 550 ALGSRVTNVK 560 VTLRLDTHPA 570 MITVLEMGAA 580 RHFLRMQQLA 590 KTQEERAQLL 600 QPTLEINPRH 610 TLIKKLSQLR 620 HSEPDLAQLL 630 VDQIYENAMI 640 TAGLSDDPRP 650 MVSRLNRLLI 660 KALERQPPAE 670 LQACGTDTYS 680 LLAQSECSLE 690 VKGGSGVGNH 700 GTLEQRPCDH 710 DPTAPDTGEV 720 PPQPTVCSVH 730 LNLRSQQVPQ 740 LISWSGKCHK PTVPQLL

Gene Ontology

Classification GO ID Description
Molecular Function GO:0019901 protein kinase binding
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0051082 unfolded protein binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.