Search Results
Overview
| Uniprot ID | A0A5G2R9A9 |
|---|---|
| Protein Name | Profilin |
| Gene Name | PFN1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | TLVLLMGKEGVHGGM |
| 167 | VHGGMINKKCYEMAS |
| 168 | HGGMINKKCYEMASH |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR
Protein Sequence
10
MLRTEVSPVG
20
AFNLENGRVR
30
GSPSPTRGPS
40
SSPESSPSSS
50
AMAGWNAYID
60
NLMADGTCQD
70
AAIVGYKDSP
80
SVWAAVPGKT
90
FVNITPAEVG
100
VLVGKDRSSF
110
FVNGLTLGGQ
120
KCSVIRDSLL
130
QDGEFTMDLR
140
TKSTGGAPTF
150
NITVTMTAKT
160
LVLLMGKEGV
170
HGGMINKKCY
180
EMASHLRRSQ
Y
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0110053 | regulation of actin filament organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.