Search Results
Overview
| Uniprot ID | A0A5G2R9H3 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | DCTN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 230 | DKFSQAAKVAELEKR |
| 236 | AKVAELEKRLTELEA |
| 304 | VNEIAKHKASVEDAD |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
Protein Sequence
10
MADPKYADLP
20
GIARNEPDVY
30
ETSDLPEDDQ
40
AEFDAFWRML
50
EELTSTSVEH
60
IIVNPNAAYD
70
KFKDKRVGTK
80
GLDFSDRIGK
90
TKRTGYESGE
100
YEMLGEGLGV
110
KETPQQKYQR
120
LLHEVQELTT
130
EVEKIKMTVK
140
ESATEEKLTP
150
VVLAKQLAAL
160
KQQLVASHLE
170
KLLGPDAAIN
180
LTDPDGALAK
190
RLLLQLEATK
200
NTKGAGSGGK
210
TTSGSPPDSS
220
LVTYELHSRP
230
EQDKFSQAAK
240
VAELEKRLTE
250
LEATVRCDQD
260
AQNPLSAGLQ
270
GACLMETVEL
280
LQAKVSALDL
290
AVLDQVEARL
300
QSVLGKVNEI
310
AKHKASVEDA
320
DTQSKVHQLY
330
ETIQRWSPIA
340
STLPELVQRL
350
VTIKQLHEQA
360
MQFGQLLTHL
370
DTTQQMIACS
380
LKDNATLLTQ
390
VQTTMRENLS
400
TVEGNFANID
ERMKKLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.