Overview
| Uniprot ID | A0A5G2R9H9 |
|---|
| Protein Name | ADP-ribosylation factor-like protein 3 |
|---|
| Gene Name | ARL3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
LSILRKLKSAPDQEV |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium
Protein Sequence
10
MGLLSILRKL
20
KSAPDQEVRI
30
LLLGLDNAGK
40
TTLLKQLASE
50
DISHITPTQG
60
FNIKSVQSQG
70
FKLNVWDIGG
80
QRKIRPYWRN
90
YFENTDILIY
100
VIDSADRKRF
110
EETGQELAEL
120
LEEEKLSCVP
130
VLIFANKQDL
140
LTAAPASEIA
150
EGLNLHTIRD
160
RVWQIQSCSA
170
LTGEGVQRQA
180
TPLGRRSGQK
190
ASKMLSRSFL
200
VAQQLKDLAL
210
LLVWLWLLLW
220
AWIRSLAWEL
230
ANATRVAPQK
240
CFLTLGFFDG
250
SIEGPVLCLV
260
SWMLNTYTPK
270
VAEPSAVTHA
280
SYPRSVLFFL
290
LAIFTALRVG
300
VCFRILQVGF
PPGGFC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.