Overview
| Uniprot ID | A0A5G2R9S8 |
|---|
| Protein Name | Phospholipase A-2-activating protein |
|---|
| Gene Name | PLAA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 259 |
DRSLRIWKHGECAQT |
| 671 |
FCNCFVGKAGQKLMM |
| 775 |
GVDSQIKKFASVSEP |
Function
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis
Protein Sequence
10
MASGATRYRL
20
SCSLPGHELD
30
VRGLVCCLYP
40
PGAFVSVSRD
50
RTTRLWVPDS
60
PNRGFTEMHC
70
MSGHSNFVSC
80
VCIIPSSDMY
90
PHGLIATGGN
100
DHNICIFSLE
110
SPAPLYVLKG
120
HKNTVCSLSS
130
GKFGTLLSGS
140
WDTTAKVWLN
150
DKCMMTLQGH
160
TAAVWAVKIL
170
PEQGLMLTGS
180
ADKTIKLWKA
190
GRCERTFSGH
200
EDCVRGLAIL
210
SETEFLSCAN
220
DASIRKWQIT
230
GECLEVFYGH
240
TNYIYSISVF
250
PNCKDFVTTG
260
EDRSLRIWKH
270
GECAQTIRLP
280
AQSIWCCCVL
290
NNGDIVVGAS
300
DGIIRVFTES
310
EDRTANAEEI
320
KAFERELSQA
330
TIDSKTGDLG
340
DINAEQLPGR
350
EHLNEPGTRE
360
GQTRLIRDGE
370
KVEAYQWSVS
380
ERRWIKIGDV
390
VGSSGANQQT
400
SGKVLYEGKE
410
FDYVFSIDVN
420
EGGPSYKLPY
430
NISDDPWLTA
440
YNFLQKNDLN
450
PMFLDQVAKF
460
IIDNTQGQML
470
GLGNTNFSDP
480
FTGGGRYVPG
490
SSSGSSNTLP
500
VADPFTGGGR
510
YVPGSANMGT
520
MMAGVDPFTG
530
NSAYQSAASK
540
TVNIYFPKKE
550
AVTFDQANPT
560
QILGKLKELN
570
GTASEDKKLT
580
EEDLVLLEKI
590
LSLICNNSSE
600
KPTAQQLQTL
610
WKAVNWPEDI
620
VFPALDILRL
630
SIKHPSVNEN
640
FCNEKEGTQF
650
SSHLINLLNP
660
KGKPANQLLA
670
LRTFCNCFVG
680
KAGQKLMMSQ
690
RESLMSQAIE
700
LKSGSNKNIH
710
IALATLTLNY
720
SVCFHKDHNI
730
EGKAQCLSVI
740
STVLEVVQDL
750
EATFRLLVAL
760
GTLISDDSNA
770
VQLAKSLGVD
780
SQIKKFASVS
790
EPAKVSECCR
LILNLL
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0007399 |
nervous system development |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0000153 |
cytoplasmic ubiquitin ligase complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0016005 |
phospholipase A2 activator activity |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Biological Process |
GO:0071222 |
cellular response to lipopolysaccharide |
| Biological Process |
GO:0016236 |
macroautophagy |
| Biological Process |
GO:1900045 |
negative regulation of protein K63-linked ubiquitination |
| Biological Process |
GO:1903861 |
positive regulation of dendrite extension |
| Biological Process |
GO:2001224 |
positive regulation of neuron migration |
| Biological Process |
GO:0031394 |
positive regulation of prostaglandin biosynthetic process |
| Biological Process |
GO:1903423 |
positive regulation of synaptic vesicle recycling |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0010992 |
ubiquitin recycling |
| Biological Process |
GO:0043162 |
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.