Search Results
Overview
| Uniprot ID | A0A5G2RA90 |
|---|---|
| Protein Name | Protein disulfide-isomerase A6 |
| Gene Name | PDIA6 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | IKIFGSNKNRPEDYQ |
| 146 | GGGYSSGKQGRSEGS |
| 156 | RSEGSGKKDVIELTD |
| 204 | AAAATEVKEQTKGKV |
| 212 | EQTKGKVKLAAVDAT |
| 237 | IRGFPTIKIFQKGES |
| 241 | PTIKIFQKGESPVDY |
| 364 | AINARKMKFALLKGS |
| 62 | QRLTPEWKKVATALK |
| 63 | RLTPEWKKVATALKD |
| 69 | KKVATALKDVVKVGA |
| 73 | TALKDVVKVGAVDAD |
| 81 | VGAVDADKHQSLGGQ |
Function
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin
Protein Sequence
10
MATLVLCTLF
20
VAVNGLYSSS
30
DDVIELTPSN
40
FNREVIQSDS
50
LWLVEFYAPW
60
CGHCQRLTPE
70
WKKVATALKD
80
VVKVGAVDAD
90
KHQSLGGQYG
100
VQGFPTIKIF
110
GSNKNRPEDY
120
QGGRTGEAIV
130
DAALSALRQL
140
VKDRLGGRGG
150
GYSSGKQGRS
160
EGSGKKDVIE
170
LTDDTFDKNV
180
LDSEDVWMVE
190
FYAPWCGHCK
200
NLEPEWAAAA
210
TEVKEQTKGK
220
VKLAAVDATV
230
NQVLASRYGI
240
RGFPTIKIFQ
250
KGESPVDYDG
260
GRTRSDIVTR
270
ALDLFSDNAP
280
PPELLEIISE
290
DVAKKSCEEH
300
QLCVVAVLPH
310
ILDTGAAGRN
320
SYLEVLLKLA
330
DKYKKKMWGW
340
LWTEAGAQTE
350
LEHALGIGGF
360
GYPAMAAINA
370
RKMKFALLKG
380
SFSEQGINEF
390
LRELSFGRGS
400
TAPVGGGAFP
410
AISTREPWDG
420
KDGEVSPATR
430
EPGDGKDGQA
440
SPATREPWDG
450
KDGQASPATR
460
EPGDGKDGEA
470
SPAEPRGQDA
480
SRLWLSFLAS
490
LGPEAGCEPG
500
LCIRAAPRAG
510
PAVAPPGPRG
520
LLLSSSSAPL
530
PPATPQAKAP
540
GSCSPGHSPQ
550
AERFSTWREA
560
QRGHFEVSLD
570
SRTLPSGLER
580
PTSVAPGVCP
RDDGRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.