Search Results
Overview
| Uniprot ID | A0A5G2RAB5 |
|---|---|
| Protein Name | Thioredoxin reductase 1, cytoplasmic |
| Gene Name | TXNRD1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | TNNKGKEKIYSAEKF |
| 169 | EKIYSAEKFLIATGE |
| 437 | DNNKCYAKIVCNIKD |
| 443 | AKIVCNIKDNERVVG |
| 81 | NVGCIPKKLMHQAAL |
Function
Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2)
Protein Sequence
10
MAYQEGRLQK
20
LLKMNGAEEL
30
PEMYDYDLII
40
IGGGSGGLAA
50
AKEAARFNKR
60
VMVLDFVTPT
70
PLGTRWGLGG
80
TCVNVGCIPK
90
KLMHQAALLG
100
QALRDSRNYG
110
WNVEETIKHD
120
WERMTEAVQN
130
HIGSLNWGYR
140
VALREKKVTY
150
ENAYGQFVGP
160
HRIKATNNKG
170
KEKIYSAEKF
180
LIATGERPRY
190
LGIPGDKEYC
200
ISSDDLFSLP
210
YCPGKTLVVG
220
ASYVALECAG
230
FLAGIGLDVT
240
VMVRSILLRG
250
FDQDMANKIG
260
EHMEEHGVKF
270
IRQFVPIKVE
280
QIEAGMPGRL
290
RVTAKATNSD
300
ETIEGEYNTV
310
LLAIGRDACT
320
RNIGLETVGV
330
EINEKTGKIP
340
VTDEEQTNVP
350
YVYAIGDILE
360
GKPELTPVAI
370
QAGRLLAQRL
380
YGGSTVKCDY
390
ENVPTTVFTP
400
LEYGACGLSE
410
EKAVEKFGEE
420
NIEIYHSYFW
430
PLEWTIPSRD
440
NNKCYAKIVC
450
NIKDNERVVG
460
FHILGPNAGE
470
VTQGFAAALK
480
CGLTKDQLDS
490
TIGIHPVCAE
500
VGHLPLMGQH
510
PLTHGANLGL
CS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0004362 | glutathione-disulfide reductase (NADPH) activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050137 | NADPH peroxidase activity |
| Molecular Function | GO:0004791 | thioredoxin-disulfide reductase (NADPH) activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0006749 | glutathione metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.