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Overview

Uniprot IDA0A5G2RAZ9
Protein NameDynein light intermediate chain
Gene NameDYNC1LI2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
201 YTSVKEEKNLDLLYK
363 FNSLLSKKTGSPGSP
8 MAPVGVEKKLLLGPN

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes

Protein Sequence

10 MAPVGVEKKL 20 LLGPNGPAVA 30 AAGDLTSEEE 40 EGQSLWSSIL 50 SEVSTRARSK 60 LPSGKNILVF 70 GEDGSGKTTL 80 MTKLQGAEHG 90 KKGRGLEYLY 100 LSIHDEDRDV 110 MKDFQDYIEP 120 EEGSQGSPQR 130 RGPLTSGPDE 140 ENVALPLGDN 150 VLTHNLGVPV 160 LVVCTKCDAV 170 SVLEKEHDYR 180 DEHFDFIQSH 190 LRRFCLQYGA 200 ALIYTSVKEE 210 KNLDLLYKYI 220 VHKTYGFHFT 230 TPALVVEKEA 240 VFIPAGWDNE 250 KKIAILHENF 260 TTVKPEDAYE 270 DFIVKPPVRK 280 LVHDKELAAE 290 DEQVFLMKQQ 300 SLLAKQPATP 310 TRASESPARG 320 PSGSPRTQGR 330 GGPASVPSAS 340 PGTSVKKPDP 350 NIKNNAASEG 360 VLASFFNSLL 370 SKKTGSPGSP 380 GAGGVQSTAK 390 KSGQKTVLTN 400 VQEELDRMTR 410 KPDSMVTNSS TENEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005868 cytoplasmic dynein complex
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Biological Process GO:0007018 microtubule-based movement

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.