Search Results

Overview

Uniprot IDA0A5G2RBV3
Protein NameUridine 5'-monophosphate synthase
Gene NameUMPS
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
101 LIRRKEAKDYGTKRL
314 FLIFEDRKFADIGNT
324 DIGNTVKKQYAGGVF
465 NRLEAAEKYRKAAWE

Function

Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP)

Protein Sequence

10 MAAADVALAS 20 LVTGLYDVQA 30 FKFGSFVLKS 40 GLSSPVYIDL 50 RGIVSRPRLL 60 SQVAEILFQT 70 AQNAGINFDT 80 VCGVPYTALP 90 LATVICSTNQ 100 IPMLIRRKEA 110 KDYGTKRLIE 120 GAVNPGETCL 130 IIEDVVTSGS 140 SILETVEVLQ 150 KEGLKVTDAI 160 VVLDREQGGR 170 DKLQAHGIRL 180 HSVCTLSNML 190 EILEQQKKID 200 AEMVERVKRF 210 IQENVFVVAN 220 HNGSLPSAKK 230 APKELSFGTR 240 AELPGIHPVA 250 SKLLRLMQKK 260 ETNLCLSADI 270 SESRELLQLA 280 DALGPSICML 290 KTHVDILNDF 300 TPDVMKELTT 310 LAKRHEFLIF 320 EDRKFADIGN 330 TVKKQYAGGV 340 FKIASWADIV 350 NAHVVPGSGV 360 VKGLREVGLP 370 LHRACLLIAE 380 MSSAGSLATG 390 SYTEAAVRMA 400 EEHSEFVVGF 410 ISGSRVSMKP 420 EFLHLTPGVQ 430 LEAGGDNLGQ 440 QYNSPQEVIG 450 KRGSDIIIVG 460 RGILMSANRL 470 EAAEKYRKAA 480 WEAYLSRLAV

Gene Ontology

Classification GO ID Description
Molecular Function GO:0004588 orotate phosphoribosyltransferase activity
Molecular Function GO:0004590 orotidine-5'-phosphate decarboxylase activity
Biological Process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Biological Process GO:0044205 'de novo' UMP biosynthetic process
Biological Process GO:0019856 pyrimidine nucleobase biosynthetic process
Biological Process GO:0006222 UMP biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.