Search Results

Overview

Uniprot IDA0A5G2RC42
Protein NameAlpha-1,4 glucan phosphorylase
Gene NamePYGL
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
29 VENVAELKKGFNRHL
387 KIAALFPKDVDRLRR
42 HLHFTLVKDRNVATP
431 KIHSDIVKTQVFKDF
505 LREISNVKQENKLKF
511 VKQENKLKFSQFLEK
690 EDVAALDKKGYNAKE
78 TQQYYYEKCPKLGLD

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDQEK 20 RRQISIRGIV 30 GVENVAELKK 40 GFNRHLHFTL 50 VKDRNVATPR 60 DYFFALAHTV 70 RDHLVGRWIR 80 TQQYYYEKCP 90 KLGLDMEELE 100 EIEEDAGLGN 110 GGLGRLAACF 120 LDSMATLGLA 130 AYGYGIRYEY 140 GIFNQKIRDG 150 WQIEEADDWL 160 RHGNPWEKAR 170 PEFMLPVHFY 180 GRVEHTEAGT 190 KWVDTQVVLA 200 LPYDTPVPGY 210 LNNTVNTMRL 220 WSARAPNDFN 230 LRDFNVGDYI 240 QAVLDRNLAE 250 NISRVLYPND 260 NFFEGKELRL 270 KQEYFVVAAT 280 LQDVIRRFKA 290 SKFGSSDSAG 300 TAFDAFPDQV 310 AIQLNDTHPA 320 LAIPELMRIF 330 VDIEKLPWSK 340 AWGITQKTFA 350 YTNHTVLPEA 360 LERWPVELVE 370 KLLPRHLQII 380 YEINQKHLDK 390 IAALFPKDVD 400 RLRRMSLIEE 410 EGGKRINMAH 420 LCIVGSHAVN 430 GVAKIHSDIV 440 KTQVFKDFSE 450 LEPDKFQNKT 460 NGITPRRWLL 470 LCNPGLAELI 480 AEKIGEDYVK 490 DLSQLTKLHH 500 FLGDDVFLRE 510 ISNVKQENKL 520 KFSQFLEKEY 530 KVKINPASMF 540 DVQVKRIHEY 550 KRQLMNCLHV 560 ITMYNRIKKD 570 PKKLFVPRTV 580 IIGGKAAPGY 590 HMAKLIIKLI 600 TSVAEVVNND 610 PVVGSKLKVI 620 FLENYRVSLA 630 EKVIPATDLS 640 EQISTAGTEA 650 SGTGNMKFML 660 NGALTIGTMD 670 GANVEMAEEA 680 GEENLFIFGM 690 RVEDVAALDK 700 KGYNAKEYYE 710 ALPELKLAID 720 QIDKGFFSPK 730 QPDLFKDLVN 740 MLFHHDRFKV 750 FADYEAYVKC 760 QEKVSQLYMN 770 PKAWNTMVLK 780 NIAAAGKFSS 790 DRTIKEYARD 800 IWNMEPSDLK 810 ISLSSEPSGG VHKANGK

Gene Ontology

Classification GO ID Description
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0005977 glycogen metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.