Search Results
Overview
| Uniprot ID | A0A5G2RCL1 |
|---|---|
| Protein Name | Cytosolic Fe-S cluster assembly factor NUBP1 |
| Gene Name | NUBP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | KILVLSGKGGVGKST |
| 296 | KEISFCHKVKLPIIG |
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure
Protein Sequence
10
MCFCCDTKEI
20
PTKVLGIDLC
30
SSILKGTETP
40
QAPDHRICGT
50
HALSLRFISR
60
SWRIRLGASR
70
RKYATAVSGD
80
RRGVQSSRME
90
EVPHDCPGTG
100
SAQAGRGASC
110
QGCPNQRLCA
120
SGAGAAPDPA
130
IEEIKEKMKT
140
VKHKILVLSG
150
KGGVGKSTFS
160
AHLAHGLAED
170
ENTQVALLDI
180
DICGPSIPKI
190
MGLEGEQVHQ
200
SGSGWSPVFL
210
EDNLGVMSVG
220
FLLSSPDDAV
230
IWRGPKKNGM
240
IKQFLRDVDW
250
GELDYLIVDT
260
PPGTSDEHLS
270
AVQYLAGAHI
280
DGAVLITTPQ
290
EVSLQDVRKE
300
ISFCHKVKLP
310
IIGVVENMSS
320
FLCPRCQKES
330
QIFPPTTGGA
340
EVMCQDLKIP
350
LLGKVPLDPR
360
IAKSCDKGQS
370
FLVEAPDSPA
380
TLAYRSIIQR
390
IREFCDLRPP
EGANHVAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140663 | ATP-dependent FeS chaperone activity |
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
| Biological Process | GO:0001558 | regulation of cell growth |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.