Overview
| Uniprot ID | A0A5G2RCL6 |
|---|
| Protein Name | Sorting nexin |
|---|
| Gene Name | SNX9 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 396 |
TVGQEHWKRCTGPLP |
Function
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate
Protein Sequence
10
MATKARVMYD
20
FAAEPGNNEL
30
TVSEGEIITI
40
TNPDVGGGWL
50
EGRNSKGERG
60
LVPTDYVEIL
70
PSDGKDPFSC
80
GNSVADQAFL
90
DSLSASTAQA
100
NSAAASGANQ
110
VDILAQIGCV
120
ESLSQSPHSS
130
SPSPSINKTG
140
DDDDWDEDWD
150
EPKSSSPYFK
160
DGESAEAGGA
170
QRGNSRAGSS
180
SMKLPLNKFP
190
GFAKPGMEQY
200
LLAKQLAKPK
210
EKIPIIVGDY
220
GPMWVYPTST
230
FDCVVADPRK
240
GSKMYGLKSY
250
IEYQLTPTNT
260
NRSVNHRYKH
270
FDWLYERLLV
280
KFGLAIPIPS
290
LPDKQVTGRF
300
EEEFIKMRME
310
RLQAWMSRMC
320
RHPVISESEV
330
FQQFLNFRDE
340
KEWKTGKRKA
350
EKDELVGVMV
360
FSTMEPEAPD
370
LDLVEIEQKC
380
EAVGKFTKAM
390
DDGVKELLTV
400
GQEHWKRCTG
410
PLPKEYQKIG
420
KALQSLATVF
430
SSSGYQGETD
440
LNDAITEAGK
450
TYEEIASLVA
460
EQPKKDLHFL
470
MECNHEYKGF
480
LGCFPDIIGT
490
HKGAIEKVKE
500
SDKLVATSKI
510
TPQDKQNMVK
520
RVGTMSYALQ
530
AEMNHFHSNR
540
IYDYNSVIRL
550
YLEQQVQFYE
560
TIAEKLRQAL
GRFPVM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030136 |
clathrin-coated vesicle |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0001726 |
ruffle |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0000281 |
mitotic cytokinesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.