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Overview

Uniprot ID	A0A5G2RDH5
Protein Name	Long-chain-fatty-acid--CoA ligase
Gene Name	ACSL1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
402	IQSSLGGKVRLMVTG

Function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation

Protein Sequence

10 MMQAHELFRY 20 FRMPELVDFQ 30 QYVRTLPTNT 40 LMGFGAFAAL 50 TTFWYATRPR 60 ALKPPCDLAM 70 QSVEVAGSDG 80 ARRSAILDSD 90 EPLAYFYDDV 100 RTLYEGFQRG 110 IRVSNNGPCL 120 GSRKPDQPYE 130 WLSYKQVEDM 140 SECVGSALIH 150 KGFKAGPENF 160 VGIFAQNRPE 170 WVIIEQGCFA 180 YSMVVVPLYD 190 TLGTEAITYI 200 INKGELSLVF 210 VDKPEKANLL 220 LEGVENKLIP 230 GLKTIILMDS 240 YGIDLLERGK 250 KCGVEIMSMK 260 ALEDLGRANR 270 RKPKPPAPED 280 LAVICFTSGT 290 TGNPKGAMIT 300 HRNVVSDCSA 310 FVKVTECVML 320 CHGAKIGFFQ 330 GDIRLLMDDL 340 KALQPTIFPV 350 VPRLLNRMFD 360 RIFGQANTTL 370 KRWLLDFASK 380 RKEAELRSGI 390 IRNNSLWDKL 400 IFHKIQSSLG 410 GKVRLMVTGA 420 APVSATVLTF 430 LRAALGCQFY 440 EGYGQTECTA 450 GCSLTVPGDW 460 TAGHVGAPMP 470 CSLIKLVDVE 480 EMNYLAAKGE 490 GEVCVKGPNV 500 FQGYLKDPAK 510 TAEALDKDGW 520 LHTGDIGKWL 530 PNGTLKIIDR 540 KKHIFKLAQG 550 EYIAPEKIEN 560 IYLRSEPVAQ 570 VFVHGESLQA 580 FLIAIVVPDV 590 ETLGHWAQKR 600 GFVGSFEELC 610 RNKDVKKAIL 620 EDMLRLGRDA 630 GLKSFEQVRG 640 ISLHPELFSI 650 DNGLLTPTMK 660 AKRPELRNYF 670 RSQIDELYST VKV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005741	mitochondrial outer membrane
Molecular Function	GO:0047676	arachidonate-CoA ligase activity
Molecular Function	GO:0005524	ATP binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.