Search Results
Overview
| Uniprot ID | A0A5G2RDX5 |
|---|---|
| Protein Name | Twinfilin-1 |
| Gene Name | TWF1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | DVSLHGYKKYLLSQS |
| 26 | NGKYRLLKISIENEK |
| 33 | KISIENEKLVIGSCR |
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles
Protein Sequence
10
KIRTKLNEDV
20
KDIFARARNG
30
KYRLLKISIE
40
NEKLVIGSCR
50
QPSDSWDKDY
60
DSFVLPMLED
70
KQPCYILFRL
80
DSQNAQGYEW
90
IFIAWSPDHS
100
HVRQKMLYAA
110
TRATLKKEFG
120
GGHIKDEVFG
130
TVKEDVSLHG
140
YKKYLLSQSS
150
PAPLTAAEEE
160
LRQIKINEVQ
170
TDVSVDTKHQ
180
TLQGVAFPIS
190
REAFQALEKL
200
NNRQLNYVQL
210
EIDIKNEVII
220
LANTVNTELK
230
DLPKRIPKDS
240
ARYHFFLYKH
250
SHEGDYLDVF
260
LSVCSLGLSC
270
SFMRERMLYS
280
SCKSPLLEIV
290
ERQLQMDVIR
300
KIEIDNGDEL
310
TADFLYEEVH
320
PKQHAHKQSF
330
AKPKGPSGKR
340
GIRRLIRGPA
ETEATTD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.