Search Results
Overview
| Uniprot ID | A0A5G2RDZ7 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha |
| Gene Name | CAPZA2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 125 | TALRAYVKEHYPNGV |
| 138 | GVCTVYGKKIDGQQT |
| 139 | VCTVYGKKIDGQQTI |
| 260 | QLPVTRTKIDWNKIL |
| 83 | NGKFLDPKNRICFKF |
| 89 | PKNRICFKFDHLRKE |
| 95 | FKFDHLRKEATDPRP |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments
Protein Sequence
10
IKLLEENIAA
20
KFIIHAPPGE
30
FNEVFNDVRL
40
LLNNDNLLRE
50
GAAHAFAQYN
60
LDQFTPVKIE
70
GYEDQVLITE
80
HGDLGNGKFL
90
DPKNRICFKF
100
DHLRKEATDP
110
RPYEAENAVE
120
SWRTSVETAL
130
RAYVKEHYPN
140
GVCTVYGKKI
150
DGQQTIIACI
160
ESHQFQAKNF
170
WNGRWRSEWK
180
FTITPSTTQV
190
VGILKIQVHY
200
YEDGNVQLVS
210
HKDIQDSLTV
220
SNEVQTAKEF
230
IKIVEAAENE
240
YQTAISENYQ
250
TMSDTTFKAL
260
RRQLPVTRTK
270
IDWNKILSYK
IGKEMQNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.