Search Results
Overview
| Uniprot ID | A0A5G2REB0 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha |
| Gene Name | CAPZA2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | TALRAYVKEHYPNGV |
| 139 | GVCTVYGKKIDGQQT |
| 140 | VCTVYGKKIDGQQTI |
| 261 | QLPVTRTKIDWNKIL |
| 84 | NGKFLDPKNRICFKF |
| 90 | PKNRICFKFDHLRKE |
| 96 | FKFDHLRKEATDPRP |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments
Protein Sequence
10
VCDFIDTQIS
20
AKFIIHAPPG
30
EFNEVFNDVR
40
LLLNNDNLLR
50
EGAAHAFAQY
60
NLDQFTPVKI
70
EGYEDQVLIT
80
EHGDLGNGKF
90
LDPKNRICFK
100
FDHLRKEATD
110
PRPYEAENAV
120
ESWRTSVETA
130
LRAYVKEHYP
140
NGVCTVYGKK
150
IDGQQTIIAC
160
IESHQFQAKN
170
FWNGRWRSEW
180
KFTITPSTTQ
190
VVGILKIQVH
200
YYEDGNVQLV
210
SHKDIQDSLT
220
VSNEVQTAKE
230
FIKIVEAAEN
240
EYQTAISENY
250
QTMSDTTFKA
260
LRRQLPVTRT
270
KIDWNKILSY
KIGKEMQNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.