Search Results
Overview
| Uniprot ID | A0A5G2RF87 |
|---|---|
| Protein Name | CDGSH iron-sulfur domain-containing protein 2 |
| Gene Name | CISD2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | YCRCWRSKTFPACDG |
| 111 | ACDGSHNKHNELTGD |
| 126 | NVGPLILKKKEV*** |
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy
Protein Sequence
10
SCLGSCVRPL
20
LGTWRHRVLI
30
LVAVSFVFCV
40
SEWLRLLPFL
50
GVLALLGYLA
60
VRPFLPKKKQ
70
QKDSLINLKI
80
QKENPKVVNE
90
INIEDLCLTK
100
AAYCRCWRSK
110
TFPACDGSHN
120
KHNELTGDNV
130
GPLILKKKEV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0010506 | regulation of autophagy |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.