Search Results
Overview
| Uniprot ID | A0A5G2RG05 |
|---|---|
| Protein Name | Mitogen-activated protein kinase |
| Gene Name | MAPK1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 263 | KVRVAIKKISPFEHQ |
| 480 | LSLPHKNKVPWNRLF |
| 552 | DLPKEKLKELIFEET |
Function
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity
Protein Sequence
10
MQISLSVSVT
20
LPASVRVSRP
30
LICMGPGLSQ
40
TWLGARGRGE
50
SAPVALLLGG
60
SRPELLSARC
70
PARSAPQARP
80
ASESSAFPRR
90
LPRAHVTAPR
100
PAAAVLRPQR
110
ASSAGRAALP
120
PGRGSQSALT
130
PTALPRRPPR
140
RAPLPPPAGP
150
PVSQSGGQSV
160
RAVGGYLPLP
170
SGSLTDSSRP
180
AAAAAAAGAR
190
SPRWCSVGRA
200
AAAEHRAQCG
210
GGGGGPAANM
220
AAAAAGAGPE
230
MVRGQVFDVG
240
PRYTNLSYIG
250
EGAYGMVCSA
260
YDNVNKVRVA
270
IKKISPFEHQ
280
TYCQRTLREI
290
KILLRFRHEN
300
IIGINDIIRA
310
PTIEQMKDVY
320
IVQDLMETDL
330
YKLLKTQHLS
340
NDHICYFLYQ
350
ILRGLKYIHS
360
ANVLHRDLKP
370
SNLLLNTTCD
380
LKICDFGLAR
390
VADPDHDHTG
400
FLTEYVATRW
410
YRAPEIMLNS
420
KGYTKSIDIW
430
SVGCILAEML
440
SNRPIFPGKH
450
YLDQLNHILG
460
ILGSPSQEDL
470
NCIINLKARN
480
YLLSLPHKNK
490
VPWNRLFPNA
500
DSKALDLLDK
510
MLTFNPHKRI
520
EVEQALAHPY
530
LEQYYDPSDE
540
PIAEAPFKFD
550
MELDDLPKEK
560
LKELIFEETA
RFQPGYRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004707 | MAP kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Biological Process | GO:0006915 | apoptotic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.