Search Results
Overview
| Uniprot ID | A0A5G2RG98 |
|---|---|
| Protein Name | Basement membrane-specific heparan sulfate proteoglycan core protein |
| Gene Name | HSPG2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1342 | KVAAYGGKLRYSLSY |
| 1724 | VTFICTAKSKSPAYT |
| 1726 | FICTAKSKSPAYTLV |
| 296 | DEADCPVKRPEDVCG |
| 730 | GPQCNKCKAGFFGDA |
Function
Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6
Protein Sequence
10
MTNPLLPPHF
20
LPQLEDAGSE
30
AFREVSEAVV
40
DTLESEYLKI
50
PGDQVVSVVF
60
IKELDSWVFV
70
ELDVGSEGNA
80
DGAQIQEVLH
90
AVISSGSIAS
100
YVTSPQGFQF
110
RRLGTAQTPP
120
PPLAAVAAAV
130
TPVPQFSRVC
140
TEAEFACHRY
150
NECVALEYRC
160
DRRPDCRDMS
170
DELDCEEPVP
180
VLSSLPPTLA
190
ETPPLPPSPP
200
EPEAATARQL
210
PATPAPQALF
220
PSPDKAAPCG
230
PHEATCRSGH
240
CIPKDYVCDG
250
QEDCRDGSDE
260
LDCGPAPPCE
270
PNEFPCGNGH
280
CALKLWRCDG
290
DFDCEDRTDE
300
ADCPVKRPED
310
VCGPTQFRCV
320
STNTCIPASF
330
HCDEESDCPD
340
RSDEFGCMPP
350
QVVTPPQESI
360
QASRGQTVTF
370
TCVAIGVPTP
380
IINWRLNWGH
390
IPSHPRVTVT
400
SEGGRGTLII
410
RDVKEADQGA
420
YTCEAMNARG
430
MVFGIPDGVL
440
ELIPQRGPCP
450
DGHFYLEQSA
460
SCLPCFCFGV
470
TNVCQSSRRF
480
RDKIRLRFDQ
490
PNDFKGVNVT
500
MPSQPGMPPL
510
SSTQLQIDAA
520
LQEFQLVDLS
530
RRFLVHDSFW
540
ALPEQFLGNK
550
VDSYGGFLHY
560
KVRYELARGT
570
LEPVQRPDVV
580
LVGAGHRLLS
590
RGHTPTQPGT
600
LNQRQVQFSE
610
EHWVHESGRP
620
VQRAEMLQVL
630
QSLEAVLIQT
640
VYNAKMASVG
650
LSDISMDTTV
660
TYATSHGRAH
670
SVEECRCPIG
680
YSGLSCESCD
690
AHFTRVPGGP
700
YLGTCSGCSC
710
NGHASSCDPV
720
YGHCLNCQHN
730
TEGPQCNKCK
740
AGFFGDATKG
750
TATACRPCPC
760
PYIDASRRFS
770
DTCFLDTDGQ
780
ATCDACAPGY
790
TGRRCESCAP
800
GYEGNPIQPG
810
GKCRPTNQQI
820
VRCDERGSTG
830
TSGEACRCKN
840
NVVGRLCNEC
850
VAGSFHLSAR
860
NPDGCLKCFC
870
MGVSRQCTSS
880
SWSRAQVLGA
890
SEEPAQFSLT
900
NAAGTHTTSE
910
GISSPTPGEL
920
AFSSFHSLLS
930
GPYFWSLPSR
940
FLGDKVTSYG
950
GELRFTVTQR
960
PQPGSVPLHG
970
QPLVVLQGNN
980
IILEHHTSQE
990
PSPGQPSTFT
1000
VPFREQAWQR
1010
PDGQPATREH
1020
LLMALAGIDT
1030
LLIQASYTQR
1040
PAESRVSGIS
1050
MDVAVPEDTG
1060
QDPALEVEQC
1070
TCPPGYRGPS
1080
CQDCDTGYTR
1090
MPSGLYLGTC
1100
ERCSCHGHTE
1110
VCEPETGACQ
1120
GCQHHTEGPR
1130
CEQCQPGYYG
1140
DAQRGTPQDC
1150
QPCPCHGAPA
1160
AGQATHTCFL
1170
DTDGHPTCDA
1180
CSPGHSGRHC
1190
LGFHLWCPST
1200
SGDDGQVPEP
1210
ISCSCDPQGS
1220
ISNQCDAAGQ
1230
CQCKAQVEGL
1240
TCSHCRPHHF
1250
YLSASNPDGC
1260
LPCFCMGVTQ
1270
QCSSSSYTRH
1280
LISTRFAPGD
1290
FQGFALVNPQ
1300
RNSRLTGGFT
1310
VEPVPEGAQL
1320
SFGNFANLGH
1330
ESFYWQLPET
1340
YQGDKVAAYG
1350
GKLRYSLSYT
1360
AGAQGSPLSD
1370
PDVQITGNNI
1380
MLVASQPALQ
1390
GPERRSYEII
1400
FREEFWRRPD
1410
GQPATREHLL
1420
MALADLDELL
1430
VRATFSSMPL
1440
AASISAVSLE
1450
VAQPGPSEGP
1460
RAPEVEECRC
1470
PPGYVGSSCQ
1480
DCAPGYTRTG
1490
SGLYLGHCEL
1500
CECNGHSDLC
1510
HPETGACSQC
1520
QHNAAGEFCE
1530
LCAPGYYGDA
1540
TAGTPEDCQP
1550
CACPLTNPEN
1560
MFSRTCESLG
1570
AGGYRCTACE
1580
PGYTGQYCEQ
1590
CAPGYVGNPN
1600
VRGGRCLPQA
1610
DQAPLVVQVQ
1620
PPRSVVPQGG
1630
PHSLRCQVSG
1640
SPPHYFYWSR
1650
EDGRPLPSST
1660
QQRHQGSELH
1670
FPSVQPSDAG
1680
VYICTCRNLH
1690
HANTSRAELL
1700
VTEAPSKPIT
1710
VTVEEQRSQS
1720
VRPGTDVTFI
1730
CTAKSKSPAY
1740
TLVWTRLHNG
1750
KLPTRAMDFN
1760
GILTIRNVQP
1770
SDAGTYVCTG
1780
SNMFAMDQGT
1790
ATLHVQASGT
1800
PSAPMASIHP
1810
PQLTVQPGQL
1820
AEFRCSATGN
1830
PTPTLEWTGG
1840
PGGQLPQKAQ
1850
ILGGILRLPA
1860
VEPSDQAQYL
1870
CHAHSSAGQH
1880
VARAVLHVHG
1890
GNGPRVQVSP
1900
ERTQVHEGRT
1910
VRLYCRAAGV
1920
PSATITWRKE
1930
GGSLPPQARS
1940
ERTDIATLLI
1950
PAITTADAGF
1960
YLCVATSPAG
1970
TAQARIQVVV
1980
LPASGASSPP
1990
PVRIESSSPS
2000
VTEGQTLDLN
2010
CVVTGLAYTQ
2020
VTWYKRGGSL
2030
PPHAQVHGPR
2040
LRLSHVSPAD
2050
SGEYVCRVEN
2060
ESGPKEASII
2070
VSVLHSTHSA
2080
YTPAPGGAPA
2090
PGSTHPIRIE
2100
SSSSHVAEGQ
2110
TLDLNCVVPG
2120
QAHAQVTWHR
2130
RGGSLPARHQ
2140
THGSRLRLHQ
2150
VSPADSGEYV
2160
CRVVLGSGPL
2170
ESSVLVTIEA
2180
SDSGTGSIPR
2190
PIPPVRIESS
2200
SPTVAEGQTL
2210
DLNCVVAGQA
2220
HAQVTWYKRG
2230
GSLPARHQVR
2240
GSRLYIFQAS
2250
PADAGEYVCR
2260
ASNGVEATIT
2270
VTVTRTQGAN
2280
FAYPPGSTPI
2290
RIEPSSSHVA
2300
EGQTLDLNCV
2310
VPGQAHAQVT
2320
WHKRGGSLPA
2330
RHQTHGSLLR
2340
LYQVSPADSG
2350
EYVCRIVGGS
2360
VPLEASVLVT
2370
IEPADSVPAL
2380
GVTPPVRIES
2390
SSSHVAEGQT
2400
LDLNCLVSGQ
2410
AHAQVTWHKR
2420
GGSLPARHQV
2430
HGSRLRLPQV
2440
TPADSGEYVC
2450
RVVSSSGTQE
2460
ASVLVTIQQR
2470
LGPSRPQSVV
2480
YPVRIESSSD
2490
SLANGHTLDL
2500
NCLVASQAPH
2510
TITWYKRGGS
2520
LPSRHQIVGS
2530
RLRIPQVTPA
2540
DSGEYVCHVS
2550
NGAGSQETSL
2560
IVTIQGGGSS
2570
HVPSVSPPIR
2580
IESSSPTVVE
2590
GQTLDLTCVV
2600
AGQPQATITW
2610
YKRGGSLPAR
2620
HQAHGSHLRL
2630
HQMSVADSGE
2640
YVCRANNNID
2650
AQEASIVVSV
2660
SPSTRSPAVP
2670
GGAMPIRIES
2680
SSSHVAEGQT
2690
LDLNCVVPGQ
2700
AHAQVTWHKR
2710
GGSLPTHHQA
2720
HGSRLRLYQL
2730
SPADSGEYVC
2740
RVVSSSGPLE
2750
ASVLVTIEAS
2760
GSGTVLVPAA
2770
GGTPPIRIET
2780
SSSHVAEGQT
2790
LDLKCVVPGQ
2800
AHAQVTWHRR
2810
GGSLPARHQV
2820
HGPLLRLNQV
2830
SPADSGEYSC
2840
RVTGSSGTQE
2850
ASVLVTIEAS
2860
SPSPIPAPGL
2870
AQPIYIEASS
2880
SHVTEGQTLD
2890
LNCVVPGQAH
2900
AQVTWHKHGG
2910
SLPARHQTHG
2920
SRLRLHQVSQ
2930
ADSGEYVCRV
2940
VGISGPELEA
2950
SFTVTVPPSA
2960
GSSYRLRSPV
2970
ISIDPPSSTV
2980
QQGQDASFKC
2990
LIHDGAAPIS
3000
LEWKTRNQEL
3010
EDNVHISPNG
3020
SIITIVGTRP
3030
SNHGAYRCVA
3040
SNAYGVAQSV
3050
VTLSVHGPPT
3060
VSVLPEGPVR
3070
VKEGKAITLE
3080
CVSAGEPRSS
3090
ARWTRIGAPT
3100
NLEQRLHGLL
3110
DSHTLLQISS
3120
AKPSDAGIYV
3130
CLAQNALGTA
3140
QKRVEVIVDT
3150
GIMAPGAPQV
3160
QVEEAELTVE
3170
AGHTATLRCS
3180
ATGSPTPTIH
3190
WSKLRSPLPW
3200
QHQLEGDTLI
3210
IPRVAQQDSG
3220
QYICNATSPA
3230
GHAEATIALH
3240
VESPPYATTV
3250
PEHASVRAGE
3260
TVHLQCLAHG
3270
TPPLTFQWSR
3280
VGGNLPSRVT
3290
ARKEMLLFEP
3300
AAPEDSGRYR
3310
CRVTNKVGSA
3320
EAFAQVLVQG
3330
PSGSLPATPH
3340
PAGATPAVQV
3350
TPQLETKSIG
3360
ASVEFHCIVP
3370
SDQGTQLRWV
3380
KEGGQLPPGH
3390
SVHDGVLRIQ
3400
NLDQSCQGTY
3410
VCQAYGPWGQ
3420
AQASAQLVVQ
3430
ALPSVLINIR
3440
TSVQTVVVGH
3450
SVEFECLALG
3460
DPKPQVTWSK
3470
VGGPLRPGIV
3480
QTGGIVRIAH
3490
VELADAGQYR
3500
CTATNAAGTT
3510
QSHVLLLVQA
3520
LPQISTPPEV
3530
RVPAGSAAVF
3540
PCMASGYPTP
3550
DISWSKLDGN
3560
LPPDSRLENN
3570
MLLLPSVRPQ
3580
DAGTYVCTAT
3590
NRQGKVKAFA
3600
HLQVPERVVP
3610
YFTQTPHSFL
3620
PLPTIKDAYR
3630
KFEIKITFRP
3640
DSADGDRACP
3650
GMLLYNGQKR
3660
IPGSPTNLAN
3670
RQPDFISFGL
3680
VGGRPEFRFD
3690
AGSGMATIRH
3700
PTPLALGQFH
3710
TVTLLRSLTQ
3720
GSLIVGSLTP
3730
VNGTSQGKFQ
3740
GLDLNEELYL
3750
GGYPDYGAIP
3760
KAGLSSGFVG
3770
CVRELRIQGE
3780
EIVFHDLNLT
3790
AHGISHCPTC
3800
RDRPCQNGGH
3810
CQDSESSSYV
3820
CMCPAGFTGS
3830
RCEHSQALHC
3840
HPEACGPDAT
3850
CVNRPDGRGY
3860
TCRCHLGRSG
3870
RRCEEGVTVT
3880
TPSMSGTGSY
3890
LALPALTNTH
3900
HELRLDVEFK
3910
PLAPDGILVF
3920
SGGQSGPVED
3930
FVSLAMVGGH
3940
LEFRYELGSG
3950
LAILRSSEPL
3960
ALGRWHHVSA
3970
ERFNKDGSLR
3980
VNGGRPVLRS
3990
SPGKSQGLNL
4000
HTLLYLGGVE
4010
PSVQLPPATN
4020
VSAHFHGCIG
4030
EVSVNGKRLD
4040
LTYSFLGSRG
4050
IGQCYDSSPC
4060
ERQPCQNGAT
4070
CMPAGEYEFQ
4080
CLCRDGFKGD
4090
LCEHEENPCQ
4100
LHEPCLHGGT
4110
CQGTRCLCPP
4120
GFSGPRCQQG
4130
SVHGIAESDW
4140
HLEGSGGNDA
4150
PGQYGAYFYD
4160
DGFLALPGRV
4170
FSRSLPEVPE
4180
TIELEVRTST
4190
ASGLLLWQGV
4200
EVGESGRGKD
4210
FISLGLQDGH
4220
LVFSYQLGSG
4230
EARLVSEDPI
4240
NDGEWHRVTA
4250
LREGRRGSIQ
4260
VDGEELVSGQ
4270
SPGPNVAVNT
4280
KGSVYIGGAP
4290
DVAALTGGRF
4300
SSGITGCIKN
4310
LVLHSARPGA
4320
LPPQPLDLQH
4330
RAQAGANMRP
CPS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0005796 | Golgi lumen |
| Molecular Function | GO:0005509 | calcium ion binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0030154 | cell differentiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.