Search Results

Overview

Uniprot IDA0A5G2RG98
Protein NameBasement membrane-specific heparan sulfate proteoglycan core protein
Gene NameHSPG2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1342 KVAAYGGKLRYSLSY
1724 VTFICTAKSKSPAYT
1726 FICTAKSKSPAYTLV
296 DEADCPVKRPEDVCG
730 GPQCNKCKAGFFGDA

Function

Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6

Protein Sequence

10 MTNPLLPPHF 20 LPQLEDAGSE 30 AFREVSEAVV 40 DTLESEYLKI 50 PGDQVVSVVF 60 IKELDSWVFV 70 ELDVGSEGNA 80 DGAQIQEVLH 90 AVISSGSIAS 100 YVTSPQGFQF 110 RRLGTAQTPP 120 PPLAAVAAAV 130 TPVPQFSRVC 140 TEAEFACHRY 150 NECVALEYRC 160 DRRPDCRDMS 170 DELDCEEPVP 180 VLSSLPPTLA 190 ETPPLPPSPP 200 EPEAATARQL 210 PATPAPQALF 220 PSPDKAAPCG 230 PHEATCRSGH 240 CIPKDYVCDG 250 QEDCRDGSDE 260 LDCGPAPPCE 270 PNEFPCGNGH 280 CALKLWRCDG 290 DFDCEDRTDE 300 ADCPVKRPED 310 VCGPTQFRCV 320 STNTCIPASF 330 HCDEESDCPD 340 RSDEFGCMPP 350 QVVTPPQESI 360 QASRGQTVTF 370 TCVAIGVPTP 380 IINWRLNWGH 390 IPSHPRVTVT 400 SEGGRGTLII 410 RDVKEADQGA 420 YTCEAMNARG 430 MVFGIPDGVL 440 ELIPQRGPCP 450 DGHFYLEQSA 460 SCLPCFCFGV 470 TNVCQSSRRF 480 RDKIRLRFDQ 490 PNDFKGVNVT 500 MPSQPGMPPL 510 SSTQLQIDAA 520 LQEFQLVDLS 530 RRFLVHDSFW 540 ALPEQFLGNK 550 VDSYGGFLHY 560 KVRYELARGT 570 LEPVQRPDVV 580 LVGAGHRLLS 590 RGHTPTQPGT 600 LNQRQVQFSE 610 EHWVHESGRP 620 VQRAEMLQVL 630 QSLEAVLIQT 640 VYNAKMASVG 650 LSDISMDTTV 660 TYATSHGRAH 670 SVEECRCPIG 680 YSGLSCESCD 690 AHFTRVPGGP 700 YLGTCSGCSC 710 NGHASSCDPV 720 YGHCLNCQHN 730 TEGPQCNKCK 740 AGFFGDATKG 750 TATACRPCPC 760 PYIDASRRFS 770 DTCFLDTDGQ 780 ATCDACAPGY 790 TGRRCESCAP 800 GYEGNPIQPG 810 GKCRPTNQQI 820 VRCDERGSTG 830 TSGEACRCKN 840 NVVGRLCNEC 850 VAGSFHLSAR 860 NPDGCLKCFC 870 MGVSRQCTSS 880 SWSRAQVLGA 890 SEEPAQFSLT 900 NAAGTHTTSE 910 GISSPTPGEL 920 AFSSFHSLLS 930 GPYFWSLPSR 940 FLGDKVTSYG 950 GELRFTVTQR 960 PQPGSVPLHG 970 QPLVVLQGNN 980 IILEHHTSQE 990 PSPGQPSTFT 1000 VPFREQAWQR 1010 PDGQPATREH 1020 LLMALAGIDT 1030 LLIQASYTQR 1040 PAESRVSGIS 1050 MDVAVPEDTG 1060 QDPALEVEQC 1070 TCPPGYRGPS 1080 CQDCDTGYTR 1090 MPSGLYLGTC 1100 ERCSCHGHTE 1110 VCEPETGACQ 1120 GCQHHTEGPR 1130 CEQCQPGYYG 1140 DAQRGTPQDC 1150 QPCPCHGAPA 1160 AGQATHTCFL 1170 DTDGHPTCDA 1180 CSPGHSGRHC 1190 LGFHLWCPST 1200 SGDDGQVPEP 1210 ISCSCDPQGS 1220 ISNQCDAAGQ 1230 CQCKAQVEGL 1240 TCSHCRPHHF 1250 YLSASNPDGC 1260 LPCFCMGVTQ 1270 QCSSSSYTRH 1280 LISTRFAPGD 1290 FQGFALVNPQ 1300 RNSRLTGGFT 1310 VEPVPEGAQL 1320 SFGNFANLGH 1330 ESFYWQLPET 1340 YQGDKVAAYG 1350 GKLRYSLSYT 1360 AGAQGSPLSD 1370 PDVQITGNNI 1380 MLVASQPALQ 1390 GPERRSYEII 1400 FREEFWRRPD 1410 GQPATREHLL 1420 MALADLDELL 1430 VRATFSSMPL 1440 AASISAVSLE 1450 VAQPGPSEGP 1460 RAPEVEECRC 1470 PPGYVGSSCQ 1480 DCAPGYTRTG 1490 SGLYLGHCEL 1500 CECNGHSDLC 1510 HPETGACSQC 1520 QHNAAGEFCE 1530 LCAPGYYGDA 1540 TAGTPEDCQP 1550 CACPLTNPEN 1560 MFSRTCESLG 1570 AGGYRCTACE 1580 PGYTGQYCEQ 1590 CAPGYVGNPN 1600 VRGGRCLPQA 1610 DQAPLVVQVQ 1620 PPRSVVPQGG 1630 PHSLRCQVSG 1640 SPPHYFYWSR 1650 EDGRPLPSST 1660 QQRHQGSELH 1670 FPSVQPSDAG 1680 VYICTCRNLH 1690 HANTSRAELL 1700 VTEAPSKPIT 1710 VTVEEQRSQS 1720 VRPGTDVTFI 1730 CTAKSKSPAY 1740 TLVWTRLHNG 1750 KLPTRAMDFN 1760 GILTIRNVQP 1770 SDAGTYVCTG 1780 SNMFAMDQGT 1790 ATLHVQASGT 1800 PSAPMASIHP 1810 PQLTVQPGQL 1820 AEFRCSATGN 1830 PTPTLEWTGG 1840 PGGQLPQKAQ 1850 ILGGILRLPA 1860 VEPSDQAQYL 1870 CHAHSSAGQH 1880 VARAVLHVHG 1890 GNGPRVQVSP 1900 ERTQVHEGRT 1910 VRLYCRAAGV 1920 PSATITWRKE 1930 GGSLPPQARS 1940 ERTDIATLLI 1950 PAITTADAGF 1960 YLCVATSPAG 1970 TAQARIQVVV 1980 LPASGASSPP 1990 PVRIESSSPS 2000 VTEGQTLDLN 2010 CVVTGLAYTQ 2020 VTWYKRGGSL 2030 PPHAQVHGPR 2040 LRLSHVSPAD 2050 SGEYVCRVEN 2060 ESGPKEASII 2070 VSVLHSTHSA 2080 YTPAPGGAPA 2090 PGSTHPIRIE 2100 SSSSHVAEGQ 2110 TLDLNCVVPG 2120 QAHAQVTWHR 2130 RGGSLPARHQ 2140 THGSRLRLHQ 2150 VSPADSGEYV 2160 CRVVLGSGPL 2170 ESSVLVTIEA 2180 SDSGTGSIPR 2190 PIPPVRIESS 2200 SPTVAEGQTL 2210 DLNCVVAGQA 2220 HAQVTWYKRG 2230 GSLPARHQVR 2240 GSRLYIFQAS 2250 PADAGEYVCR 2260 ASNGVEATIT 2270 VTVTRTQGAN 2280 FAYPPGSTPI 2290 RIEPSSSHVA 2300 EGQTLDLNCV 2310 VPGQAHAQVT 2320 WHKRGGSLPA 2330 RHQTHGSLLR 2340 LYQVSPADSG 2350 EYVCRIVGGS 2360 VPLEASVLVT 2370 IEPADSVPAL 2380 GVTPPVRIES 2390 SSSHVAEGQT 2400 LDLNCLVSGQ 2410 AHAQVTWHKR 2420 GGSLPARHQV 2430 HGSRLRLPQV 2440 TPADSGEYVC 2450 RVVSSSGTQE 2460 ASVLVTIQQR 2470 LGPSRPQSVV 2480 YPVRIESSSD 2490 SLANGHTLDL 2500 NCLVASQAPH 2510 TITWYKRGGS 2520 LPSRHQIVGS 2530 RLRIPQVTPA 2540 DSGEYVCHVS 2550 NGAGSQETSL 2560 IVTIQGGGSS 2570 HVPSVSPPIR 2580 IESSSPTVVE 2590 GQTLDLTCVV 2600 AGQPQATITW 2610 YKRGGSLPAR 2620 HQAHGSHLRL 2630 HQMSVADSGE 2640 YVCRANNNID 2650 AQEASIVVSV 2660 SPSTRSPAVP 2670 GGAMPIRIES 2680 SSSHVAEGQT 2690 LDLNCVVPGQ 2700 AHAQVTWHKR 2710 GGSLPTHHQA 2720 HGSRLRLYQL 2730 SPADSGEYVC 2740 RVVSSSGPLE 2750 ASVLVTIEAS 2760 GSGTVLVPAA 2770 GGTPPIRIET 2780 SSSHVAEGQT 2790 LDLKCVVPGQ 2800 AHAQVTWHRR 2810 GGSLPARHQV 2820 HGPLLRLNQV 2830 SPADSGEYSC 2840 RVTGSSGTQE 2850 ASVLVTIEAS 2860 SPSPIPAPGL 2870 AQPIYIEASS 2880 SHVTEGQTLD 2890 LNCVVPGQAH 2900 AQVTWHKHGG 2910 SLPARHQTHG 2920 SRLRLHQVSQ 2930 ADSGEYVCRV 2940 VGISGPELEA 2950 SFTVTVPPSA 2960 GSSYRLRSPV 2970 ISIDPPSSTV 2980 QQGQDASFKC 2990 LIHDGAAPIS 3000 LEWKTRNQEL 3010 EDNVHISPNG 3020 SIITIVGTRP 3030 SNHGAYRCVA 3040 SNAYGVAQSV 3050 VTLSVHGPPT 3060 VSVLPEGPVR 3070 VKEGKAITLE 3080 CVSAGEPRSS 3090 ARWTRIGAPT 3100 NLEQRLHGLL 3110 DSHTLLQISS 3120 AKPSDAGIYV 3130 CLAQNALGTA 3140 QKRVEVIVDT 3150 GIMAPGAPQV 3160 QVEEAELTVE 3170 AGHTATLRCS 3180 ATGSPTPTIH 3190 WSKLRSPLPW 3200 QHQLEGDTLI 3210 IPRVAQQDSG 3220 QYICNATSPA 3230 GHAEATIALH 3240 VESPPYATTV 3250 PEHASVRAGE 3260 TVHLQCLAHG 3270 TPPLTFQWSR 3280 VGGNLPSRVT 3290 ARKEMLLFEP 3300 AAPEDSGRYR 3310 CRVTNKVGSA 3320 EAFAQVLVQG 3330 PSGSLPATPH 3340 PAGATPAVQV 3350 TPQLETKSIG 3360 ASVEFHCIVP 3370 SDQGTQLRWV 3380 KEGGQLPPGH 3390 SVHDGVLRIQ 3400 NLDQSCQGTY 3410 VCQAYGPWGQ 3420 AQASAQLVVQ 3430 ALPSVLINIR 3440 TSVQTVVVGH 3450 SVEFECLALG 3460 DPKPQVTWSK 3470 VGGPLRPGIV 3480 QTGGIVRIAH 3490 VELADAGQYR 3500 CTATNAAGTT 3510 QSHVLLLVQA 3520 LPQISTPPEV 3530 RVPAGSAAVF 3540 PCMASGYPTP 3550 DISWSKLDGN 3560 LPPDSRLENN 3570 MLLLPSVRPQ 3580 DAGTYVCTAT 3590 NRQGKVKAFA 3600 HLQVPERVVP 3610 YFTQTPHSFL 3620 PLPTIKDAYR 3630 KFEIKITFRP 3640 DSADGDRACP 3650 GMLLYNGQKR 3660 IPGSPTNLAN 3670 RQPDFISFGL 3680 VGGRPEFRFD 3690 AGSGMATIRH 3700 PTPLALGQFH 3710 TVTLLRSLTQ 3720 GSLIVGSLTP 3730 VNGTSQGKFQ 3740 GLDLNEELYL 3750 GGYPDYGAIP 3760 KAGLSSGFVG 3770 CVRELRIQGE 3780 EIVFHDLNLT 3790 AHGISHCPTC 3800 RDRPCQNGGH 3810 CQDSESSSYV 3820 CMCPAGFTGS 3830 RCEHSQALHC 3840 HPEACGPDAT 3850 CVNRPDGRGY 3860 TCRCHLGRSG 3870 RRCEEGVTVT 3880 TPSMSGTGSY 3890 LALPALTNTH 3900 HELRLDVEFK 3910 PLAPDGILVF 3920 SGGQSGPVED 3930 FVSLAMVGGH 3940 LEFRYELGSG 3950 LAILRSSEPL 3960 ALGRWHHVSA 3970 ERFNKDGSLR 3980 VNGGRPVLRS 3990 SPGKSQGLNL 4000 HTLLYLGGVE 4010 PSVQLPPATN 4020 VSAHFHGCIG 4030 EVSVNGKRLD 4040 LTYSFLGSRG 4050 IGQCYDSSPC 4060 ERQPCQNGAT 4070 CMPAGEYEFQ 4080 CLCRDGFKGD 4090 LCEHEENPCQ 4100 LHEPCLHGGT 4110 CQGTRCLCPP 4120 GFSGPRCQQG 4130 SVHGIAESDW 4140 HLEGSGGNDA 4150 PGQYGAYFYD 4160 DGFLALPGRV 4170 FSRSLPEVPE 4180 TIELEVRTST 4190 ASGLLLWQGV 4200 EVGESGRGKD 4210 FISLGLQDGH 4220 LVFSYQLGSG 4230 EARLVSEDPI 4240 NDGEWHRVTA 4250 LREGRRGSIQ 4260 VDGEELVSGQ 4270 SPGPNVAVNT 4280 KGSVYIGGAP 4290 DVAALTGGRF 4300 SSGITGCIKN 4310 LVLHSARPGA 4320 LPPQPLDLQH 4330 RAQAGANMRP CPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005796 Golgi lumen
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007420 brain development
Biological Process GO:0030154 cell differentiation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.