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Overview

Uniprot IDA0A5G2RGB0
Protein NameLow-density lipoprotein receptor
Gene NameLDLR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
272 CEGPNKFKCQSGECI

Function

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization

Protein Sequence

10 MKPGIKPSSV 20 EEKCGRNEFQ 30 CRDGKCISYK 40 WICDGNTECK 50 DGSDESLETC 60 MSVTCKIGDF 70 SCGGRVNRCI 80 PESWRCDGQQ 90 DCENGSDEEG 100 CSPKTCSQDE 110 FRCQDGKCIA 120 PKFVCDSDRD 130 CLDGSDEASC 140 PTPTCGPASF 150 QCNSSTCIPE 160 LWACDGDPDC 170 EDGSDEWPQH 180 CRSHSSSLPE 190 RSNNPCSALE 200 FHCHSGECIH 210 SSWRCDGDTD 220 CKDKSDEENC 230 DVATCRPDEF 240 QCSDGTCIHG 250 SRQCDREYDC 260 KDLSDEQGCV 270 NVTLCEGPNK 280 FKCQSGECIS 290 LDKVCNSVRD 300 CRDWSDEPLK 310 ECGTNECLDN 320 KGGCSHICND 330 LKIGYECLCP 340 EGFQLVDKHR 350 CEDIDECQDP 360 DACSQICVNL 370 EGSYKCQCEE 380 GFQLEPLTKA 390 CKAIGTIAYL 400 FFTNRHEVRK 410 MTLDRSEYTS 420 LIPNLKNVVA 430 LDTEVASNRI 440 YWSDLSQRKI 450 YSTQINRAPS 460 FSSYDTIIGE 470 DLQAPDGLAV 480 DWIHSNIYWT 490 DSILGTVSVA 500 DTKGVKRKTL 510 FQEKGSKPRA 520 IVVDPVHGFM 530 YWTDWGTPAK 540 IKKGGLNGVD 550 VYSLVTEDIQ 560 WPNGITLDLS 570 GGRLYWVDSK 580 LHSISSIDVN 590 GGNRKTVLED 600 KTKLAHPFSL 610 AIFEDKVFWT 620 DVINEAIFSA 630 NRLTGSDIHL 640 MAENLLSPED 650 IVLFHNLTQP 660 RGVNWCERTA 670 LQNGGCQYLC 680 LPAPQINPRS 690 PKFTCACPDG 700 MLLAKDMRSC 710 LTETEPAGTT 720 QGPSMVNSTA 730 VGPKHTASSE 740 LTTAESVTMS 750 QHALGDVAGR 760 GVTEKPQSVG 770 ALYIVLPIAL 780 LILLFFGTFL 790 LWKNWRLKSI 800 NSINFDNPVY 810 QKTTEDEVHI 820 CRSQDGYTYP 830 SRQMVSLEDD VA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005770 late endosome
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0006897 endocytosis
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.