Search Results

Overview

Uniprot ID	A0A5G2RH13
Protein Name	SH3 and PX domain-containing protein 2B
Gene Name	SH3PXD2B
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
579	RPEPKPDKSKLFQLK
614	LRPVSKSKADPPEER
711	RPQDRTSKQDGLSPK
718	KQDGLSPKEPTCRAP
737	KTAEPVPKNAPVPLP
800	RALLVPPKAKPFLST
818	GQDDMRGKGGLGPRM
834	GKGENKDKGAAAPCP

Function

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation

Protein Sequence

10 MPPRRSIVEV 20 KVLDVQKRRV 30 PNKHYVYIIR 40 VTWSSGSTEA 50 IYRRYSKFFD 60 LQMQMLDKFP 70 MEGGQKDPKQ 80 RIIPFLPGKI 90 LFRRSHIRDV 100 AVKRLIPIDE 110 YCKALIQLPP 120 YISQCDEVLQ 130 FFETRPEDLN 140 PPKEEHVGKK 150 KSGGDLTSVD 160 PMVLEQYVVV 170 ADYQKQESSE 180 ISLSVGQVVD 190 IIEKNESGWW 200 FVSTAEEQGW 210 VPATCLEGQD 220 GGQDEFALQP 230 EEEEKYTVIY 240 PYTARDQDEM 250 NLERGAVVEV 260 IQKNLEGWWK 270 IRYQGKEGWA 280 PASYLRKSSG 290 EPSPPKPGPG 300 SPAHAGVPEL 310 DGITRQTGRE 320 KELLNNQRDG 330 RFDGRPAPDS 340 DMKQRSPKMR 350 QRPPPRRDMT 360 IPRGLNLPKP 370 PIPPQVEEEY 380 YTIAEFQTTI 390 PDGISFQAGL 400 KVEVIEKNLS 410 GWWYIQIEDK 420 EGWAPATFID 430 KYKKTSNASR 440 PNFLAPLPNE 450 VPQLRLGEAA 460 AMENSVSSEA 470 TGPSRPLPEA 480 PHGAADSGMP 490 WSKDWKGGKE 500 VLRKASSDMS 510 SCAGYEEISD 520 PDLEEKPSLP 530 PRKESIIKSE 540 GELQERERQR 550 MEQLRGASPK 560 PPGMILPMIP 570 AKHAPPGRDS 580 RRPEPKPDKS 590 KLFQLKNEMG 600 LECGHKVLAK 610 EVKKPNLRPV 620 SKSKADPPEE 630 RPEAVPPNPF 640 LKSKPQVRPK 650 PAPSPRTEPA 660 QGEDQVDICN 670 LRSKLRPAKS 680 QEKPSVDGEG 690 GHQAGGGQDM 700 AISRSFLPGE 710 GPGRPQDRTS 720 KQDGLSPKEP 730 TCRAPPRPGK 740 TAEPVPKNAP 750 VPLPQASQQR 760 PVVPPRRPPP 770 PKKTSSSRPL 780 PEVRGPQREA 790 SEVKAAPAPG 800 PGRALLVPPK 810 AKPFLSTSPG 820 GQDDMRGKGG 830 LGPRMTGKGE 840 NKDKGAAAPC 850 PGADGPKDSL 860 YVAVADFEGD 870 QDTSSFQEGT 880 VFEVREKNSS 890 GWWFCQVQSG 900 APSWEGWIPS NYLRKKP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0002102	podosome
Molecular Function	GO:0035091	phosphatidylinositol binding
Biological Process	GO:0060348	bone development
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0001654	eye development
Biological Process	GO:0007507	heart development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.