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Overview

Uniprot IDA0A5G2RHC2
Protein NameLow-density lipoprotein receptor
Gene NameLDLR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
278 CEGPNKFKCQSGECI

Function

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization

Protein Sequence

10 MKLSFIALVQ 20 EELMAMEEKC 30 GRNEFQCRDG 40 KCISYKWICD 50 GNTECKDGSD 60 ESLETCMSVT 70 CKIGDFSCGG 80 RVNRCIPESW 90 RCDGQQDCEN 100 GSDEEGCSPK 110 TCSQDEFRCQ 120 DGKCIAPKFV 130 CDSDRDCLDG 140 SDEASCPTPT 150 CGPASFQCNS 160 STCIPELWAC 170 DGDPDCEDGS 180 DEWPQHCRSH 190 SSSLPERSNN 200 PCSALEFHCH 210 SGECIHSSWR 220 CDGDTDCKDK 230 SDEENCDVAT 240 CRPDEFQCSD 250 GTCIHGSRQC 260 DREYDCKDLS 270 DEQGCVNVTL 280 CEGPNKFKCQ 290 SGECISLDKV 300 CNSVRDCRDW 310 SDEPLKECGT 320 NECLDNKGGC 330 SHICNDLKIG 340 YECLCPEGFQ 350 LVDKHRCEDI 360 DECQDPDACS 370 QICVNLEGSY 380 KCQCEEGFQL 390 EPLTKACKAI 400 GTIAYLFFTN 410 RHEVRKMTLD 420 RSEYTSLIPN 430 LKNVVALDTE 440 VASNRIYWSD 450 LSQRKIYSTQ 460 INRAPSFSSY 470 DTIIGEDLQA 480 PDGLAVDWIH 490 SNIYWTDSIL 500 GTVSVADTKG 510 VKRKTLFQEK 520 GSKPRAIVVD 530 PVHGFMYWTD 540 WGTPAKIKKG 550 GLNGVDVYSL 560 VTEDIQWPNG 570 ITLDLSGGRL 580 YWVDSKLHSI 590 SSIDVNGGNR 600 KTVLEDKTKL 610 AHPFSLAIFE 620 DKVFWTDVIN 630 EAIFSANRLT 640 GSDIHLMAEN 650 LLSPEDIVLF 660 HNLTQPRGVN 670 WCERTALQNG 680 GCQYLCLPAP 690 QINPRSPKFT 700 CACPDGMLLA 710 KDMRSCLTET 720 EPAGTTQGPS 730 MVNSTAVGPK 740 HTASSELTTA 750 ESVTMSQHAL 760 GDVAGRGVTE 770 KPQSVGALYI 780 VLPIALLILL 790 FFGTFLLWKN 800 WRLKSINSIN 810 FDNPVYQKTT 820 EDEVHICRSQ 830 DGYTYPSRQM VSLEDDVA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005770 late endosome
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0006897 endocytosis
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.