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Overview

Uniprot ID	A0A5G2RIQ7
Protein Name	Unconventional myosin-XVIIIa
Gene Name	MYO18A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1006	RRATSMRKTFTTGVA
1016	TTGVAAVKKKSLCIQ
1428	QRALQQLKKKCQRLT

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity

Protein Sequence

10 MFNLMKKDKD 20 RDGGRKEKKE 30 KKEKKERMSA 40 AELRSLEEMG 50 LRRGFFNLNR 60 SSKRDSKTRL 70 EISNPIPIKV 80 ASGSDLHLTD 90 IDSDSNRGSV 100 ILDSGHLSTA 110 SSSDDLKGEE 120 GSLRGSVLQR 130 AAKFGSLAKQ 140 NSQMIVKRFS 150 FSQRSRDESA 160 SETSTPSEHS 170 AAPSPQVEVR 180 TLEGQLTQHP 190 GPGIPRPGPR 200 SRVPELVTKR 210 FPADLRLPPV 220 MPPPPPALRE 230 LELQRRPTGD 240 FGFSLRRTTM 250 LDRGPEGQAY 260 RRVVHFAEPG 270 AGTKDLALGL 280 VPGDRLVEIN 290 GHNVESKSRD 300 EIVEMIRQSG 310 DSVRLKVQPI 320 PELSELSRSW 330 LRSGEGPRRE 340 PAHVKTEEQI 350 AAEEAWCETE 360 KVWLVHKDGF 370 SLASQLKSEE 380 LSLPEGKVRV 390 KLDHDGTILD 400 VDEDDVEKAN 410 APPCDRLEDL 420 ASLVYLNESS 430 VLHTLRQRYG 440 ASLLHTYAGP 450 SLLVLSPRGA 460 PAVYSEKVMH 470 MFKGCRREDM 480 APHIYAVAQT 490 AYRAMLMSRQ 500 DQSIILLGSS 510 GSGKTTSCQH 520 LVQYLATIAG 530 TSGNKVFSVD 540 KWQALYTLLE 550 AFGNSPTIMN 560 GNATRFSQIL 570 SLDFDQAGQV 580 ASASIQTMLL 590 EKLRVARRPA 600 GEATFNIFYY 610 LLACGDGTLR 620 TELHLNHLAE 630 NNVFGIVPLA 640 KPEEKQKAAQ 650 QFSKLQTAMR 660 VLGISPDEQK 670 ACWLILAAIY 680 HLGAAGATKE 690 AAEAGRRQFA 700 RHEWAQKAAY 710 LLGCSLEELS 720 SAIFKHQLQA 730 STLQRSTSFR 740 QGPEESSLGD 750 STGPKLSALE 760 CLEGMASGLY 770 SELFTLLISL 780 VNRALKSSQH 790 SLCSMMIVDT 800 PGFQNPEQGG 810 SARGASFEEL 820 CHNYAQDRLQ 830 RLFHERTFVQ 840 ELERYKEENI 850 EVAFDDLEPA 860 TDDSVAAVDQ 870 ACHQSLVRSL 880 ARTDERGLLW 890 LLEEEALVPG 900 ATEDALLERL 910 FSYYGPREGD 920 KKGQSPLLRS 930 SKPHHFLLGH 940 SHGTNWVEYN 950 AAGWLSYTKQ 960 NPATQNAPRL 970 LQDSQKKIIS 980 NLFLGRAGSA 990 TVLSGSIAGL 1000 EGGSQLALRR 1010 ATSMRKTFTT 1020 GVAAVKKKSL 1030 CIQIKLQVDA 1040 LIDTIKKSKL 1050 HFVHCFLPVA 1060 EGWAGEPRSA 1070 SSRRVSSSSE 1080 LDLPPGEHCD 1090 AGLLPLDVPL 1100 LRTQLRGSRL 1110 LDAMRMYRQG 1120 YPDHMVFAEF 1130 RRRFDVLAPH 1140 LTKKHGRNYI 1150 VVDERRAVEE 1160 LLESLDLEKS 1170 SCCMGLSRVF 1180 FRAGTLARLE 1190 EQRDEQTSRN 1200 LTLFQAACRG 1210 YLARQLFKKK 1220 KIQDLAIRCV 1230 QKNIKKNKGV 1240 KDWPWWKLFT 1250 TVRPLIEVQL 1260 SEEQIRNRDE 1270 EIQQLRSKLE 1280 KVEKERNELR 1290 LSSDRLETRI 1300 SELTSELTDE 1310 RNTGESASQL 1320 LDAETAERLR 1330 AEKEMKELQT 1340 QYDALKKKME 1350 VMEMEVMEAR 1360 LIRAAEVNGE 1370 VDDEDTGGEW 1380 RLKYERAVRE 1390 VDFTKKRLQQ 1400 EFEDKLEVEQ 1410 QNKRQLERRL 1420 GDLQADSDES 1430 QRALQQLKKK 1440 CQRLTAELQD 1450 TKLHLEGQQV 1460 RNHELEKKQR 1470 RFDSELSQAH 1480 EEAQREKLQR 1490 EKLQREKDTL 1500 LAEAFSLKQQ 1510 LEEKDMDIAG 1520 FTQKVVSLEA 1530 ELQDISSQES 1540 KDEASLAKVK 1550 KQLRDLEAKV 1560 KDQEEELDEQ 1570 AGTIQMLEQL 1580 KQMEVQLEEE 1590 YEDKQKVLRE 1600 KRELESKLAT 1610 LSDQVNQRDF 1620 ESEKRLRKDL 1630 KRTKALLADA 1640 QIMLDHLKNN 1650 VPSKREIAQL 1660 KNQLEESEFT 1670 CAAAVKARKA 1680 MEVEIEDLHL 1690 QIDDIAKAKT 1700 ALEEQLSRLQ 1710 REKNEIQNRL 1720 EEDQEDMNEL 1730 MKKHKAAVAQ 1740 ASRDLAQMND 1750 LQAQLEEANK 1760 EKQELQEKLQ 1770 ALQSQVEFLE 1780 QSMVDKSLVS 1790 RQEAKIRELE 1800 TRLEFERTQV 1810 KRLESLASRL 1820 KENMEKLTEE 1830 RDQRTAAENR 1840 EKEQNKRLQR 1850 QLRDTKEEMG 1860 ELARKEAEAS 1870 RKKHELEMDL 1880 ESLEAANQSL 1890 QADLKLAFKR 1900 IGDLQAAIED 1910 EMESDENEDL 1920 INSEGDSDVD 1930 SELEDRVDGV 1940 KSWLSKNKGP 1950 SKAASDDGSL 1960 KSSSPTSYWK 1970 SLAPDRSDDE 1980 HDPLDSTSRP 1990 RYTHNYLSDS 2000 DTEAKQTETN A

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0016459	myosin complex
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA
Molecular Function	GO:0003774	cytoskeletal motor activity
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006259	DNA metabolic process
Biological Process	GO:1903028	positive regulation of opsonization
Biological Process	GO:0043030	regulation of macrophage activation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.