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Overview

Uniprot IDA0A5G2RJ76
Protein NameEarly endosome antigen 1
Gene NameEEA1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1033 EKELVNEKSKLEVTN
1173 KGEGEIEKLQTKVLE
1177 EIEKLQTKVLELQRK
251 KLKDECKKLQAEYVN
318 DYTQLEEKHNEECVS
336 IQASLHQKDLDCQQL

Function

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking

Protein Sequence

10 MFQTPGRVGS 20 QGSDLDSSAA 30 PINTVDVNNE 40 SSSEGFICPQ 50 CMKSLGSADE 60 LFKHYEAVHD 70 AGNDSSQGGE 80 ALALKRDDIT 90 LLRQEVQDLQ 100 ASLKEEKWYS 110 EELKKELEKF 120 QGLQQQELKP 130 DGVVADSSAE 140 LQSLEQQLEE 150 AQTENFNIKQ 160 MKDLFEQKAA 170 QLATEIADIK 180 SKYDEEKSLR 190 EAAEQKVTHL 200 TEELNKEATI 210 IQDLKTELLQ 220 RPGIEDVAVL 230 KKELVQVQTL 240 MDNMTLERER 250 ESEKLKDECK 260 KLQAEYVNSE 270 ATISQLRSEL 280 AKGPQEVAVY 290 VQELQKLKSS 300 VNELTQKNQN 310 LTEKLQKKEL 320 DYTQLEEKHN 330 EECVSKKNIQ 340 ASLHQKDLDC 350 QQLQSRLSAS 360 ETSLQRIQAE 370 LGEKGEATQK 380 LKEELSEVET 390 KHQHLKAEFK 400 QLQQQREEKE 410 QHGLQLQSEI 420 NQLHSKLLET 430 ERQLGEAHGR 440 LKEQRQLSSE 450 KLMDKEQQVA 460 DLQLKLSRLE 470 EELKEKVANS 480 TELQHQLDKT 490 KQQHQEQQAL 500 QQSTTAKLRE 510 AQNDLEQVLR 520 QIGDKDQKIQ 530 NLEALLQESK 540 ENISFLEKER 550 EDLYAKIQAG 560 EGETAVLNQL 570 QEKNHILQEQ 580 VSLSKLHKTV 590 LSLEASINEL 600 NNQLNKRKEK 610 VSQLDIQIKA 620 KTELLLSAEA 630 AKTAQRADLQ 640 NHLDTAQNAL 650 QDKQQELNKV 660 TTQLAQVTTH 670 LQDKQEYGSQ 680 VKSHLKEYKE 690 KHLSLEQKTE 700 ELEGQIRKLE 710 ADSLEVKASK 720 EQALQDLQQQ 730 RQLNTDLELR 740 ATELSKQVEL 750 DLQKKSEALE 760 NIKQKIENLS 770 QNAKMQQEEL 780 NNKIQAAVTE 790 LHKVKMEKET 800 LVTELSGAKE 810 ELSKVSDSLK 820 NSRSEFEKES 830 QKGKAAILDM 840 EKTCKDLKHH 850 LEVQIECAHK 860 EQNELKNSLE 870 KEELRFSFSL 880 KLECNSMQGQ 890 LMQAQKSLKQ 900 KEKEEQRLQG 910 NRNELKQLTE 920 QKKKQIETEL 930 ENKLQQQSTQ 940 AAQELAAEKE 950 KISVLQNAYE 960 KNQENLKQLQ 970 SDFYGKESEL 980 LATRQDLKEG 990 LISNRNQIGN 1000 QNKLIRELKT 1010 ARTSLEQDSA 1020 KKEEQLKEHY 1030 FSIVTEKELV 1040 NEKSKLEVTN 1050 LKDARQLLIQ 1060 QKLELQGKVD 1070 SLKATLEQEK 1080 KNQQMLKEQM 1090 KKEEDELKRE 1100 FMEKETKLHS 1110 EIKEKAAAVQ 1120 KHEENEAKRT 1130 MQMTALNENL 1140 GTVKKEWQSS 1150 QRRVMLEATV 1160 QNNQDERRAL 1170 LERCLKGEGE 1180 IEKLQTKVLE 1190 LQRKLDNTTA 1200 AVQELGRENQ 1210 SLQIKHTQAL 1220 NRKWAEDNEV 1230 QNCMACGKGF 1240 SVTVRRHHCR 1250 QCGNIFCAEC 1260 SAKNALTPSS 1270 KKPVRVCDSC FNDLQG

Gene Ontology

Classification GO ID Description
Biological Process GO:0006906 vesicle fusion
Cellular Component GO:0044308 axonal spine
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098842 postsynaptic early endosome
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Molecular Function GO:0005545 1-phosphatidylinositol binding
Molecular Function GO:0030742 GTP-dependent protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0099565 chemical synaptic transmission, postsynaptic
Biological Process GO:0006897 endocytosis
Biological Process GO:0044788 host-mediated perturbation of viral process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.