Overview
| Uniprot ID | A0A5G2RJI2 |
|---|
| Protein Name | Protein SEC13 homolog |
|---|
| Gene Name | SEC13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 191 |
QKPNYIKKFASGGCD |
| 37 |
CSSDRSVKIFDVRNG |
Function
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex
Protein Sequence
10
VSVINTVDTS
20
HEDMIHDAQM
30
DYYGTRLATC
40
SSDRSVKIFD
50
VRNGGQILIA
60
DLRGHEGPVW
70
QVAWAHPMYG
80
NILASCSYDR
90
KVIIWKEENG
100
TWEKTHEHTG
110
HDSSVNSVCW
120
APHDYGLILA
130
CGSSDGAISL
140
LTYTGLGQWE
150
VKKINNAHTC
160
PQGPSMLLQM
170
IGCNAVSWAP
180
AVVPGSLIDQ
190
PSGQKPNYIK
200
KFASGGCDNL
210
IKLWKEEEDG
220
QWKEEQKLEA
230
HSDWVRDVAW
240
APSIGLPTST
250
IASCSQDGRV
260
FIWTCDDASG
270
NTWSPKLLHK
280
FNDVVWHVSW
290
SITANILAVS
300
GGDNKVTLWK
310
ESVDGQWVCI
320
SDVNKGQGSV
330
STSITEGQQN
EQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.