Search Results
Overview
| Uniprot ID | A0A5G2RKF7 |
|---|---|
| Protein Name | Rab GDP dissociation inhibitor |
| Gene Name | GDI2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | TEGSFVYKGGKIYKV |
| 181 | TFEGVDPKKTAMREV |
| 227 | CETINRIKLYSESLA |
| 286 | NGKVIGVKSEGEIAR |
| 295 | EGEIARCKQLICDPS |
| 305 | ICDPSYVKDRVEKVG |
| 310 | YVKDRVEKVGQVIRV |
| 377 | ASTTVETKEPEKEIR |
| 435 | ETTCDDIKDIYKRMT |
Function
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A
Protein Sequence
10
CRCNMGKKVN
20
NIFFCLFAIS
30
WVAPTAYYGG
40
SQECILSGIM
50
SVNGKKVLHM
60
DRNPYYGGES
70
ASITPLEDLY
80
KRFNIPGAPP
90
ASMGRGRDWN
100
VDLIPKFLMA
110
NGQLVKMLLF
120
TEVTRYLDFK
130
VTEGSFVYKG
140
GKIYKVPSTE
150
AEALASSLMG
160
LFEKRRFRKF
170
LVYVANFDEN
180
DPRTFEGVDP
190
KKTAMREVYK
200
KFDLGQDVID
210
FTGHALALYR
220
TDDYLDQPCC
230
ETINRIKLYS
240
ESLARYGKSP
250
YLYPLYGLGE
260
LPQGFARLSA
270
IYGGTYMLNK
280
PIEEIIVQNG
290
KVIGVKSEGE
300
IARCKQLICD
310
PSYVKDRVEK
320
VGQVIRVICI
330
LSHPIKNTSD
340
ANSCQIIIPQ
350
NQVNRKSDIY
360
VCMISSAHNV
370
AAQGKYIAIA
380
STTVETKEPE
390
KEIRPALELL
400
EPIEQKFVSI
410
SDLLVPKDLG
420
TDSQIFISRT
430
YDATTHFETT
440
CDDIKDIYKR
450
MTGSEFDFEE
460
MKKAPDDFCP
AK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.