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Overview

Uniprot IDA0A5G2RL17
Protein NameExtended synaptotagmin-2
Gene NameESYT2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
179 VYTENVDKRQIILDL
302 QLRFPVPKGVLRIHF
323 QGKDTYLKGLVKGKS
789 RLYLLPDKRRSGRRK

Function

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS)

Protein Sequence

10 MSGPRAPGPE 20 AGAAGAEPPG 30 AALSVDVTGL 40 LAQLARSFAL 50 LLPVYALGYL 60 GLSFSWVLLA 70 LGLLVWCRRS 80 RGLKATRLCR 90 ALALLEDEER 100 AVRLGVRACD 110 LPAWVHFPDT 120 ERAEWLNKTV 130 KHMWPFICQF 140 IEKLFRETIE 150 PAVRGAHPHL 160 STFSFTRVDV 170 GQQPLRINGV 180 KVYTENVDKR 190 QIILDLQISF 200 VGNCEIDLEI 210 KRYFCRAGVQ 220 SIQIHGTMRV 230 ILEPLIGDMP 240 LVGALSIFFL 250 RKPLLEINWT 260 GLTNLLDIPG 270 LNGLSDTIIL 280 DIISNYLVLP 290 NRVTVPLVSE 300 VQIAQLRFPV 310 PKGVLRIHFI 320 EAQDLQGKDT 330 YLKGLVKGKS 340 DPYGVLRVGN 350 QIFQSKVIKE 360 SLSPKWNEVY 370 EALVYEHPGQ 380 ELEIELFDED 390 PDKDDFLGSL 400 MIDLIEVEKE 410 RLLDEWFALD 420 EVPKGKLHLK 430 LEWLTLVPNA 440 VNLEKVLTDI 450 RADKDQATDG 460 LSSSLLILYL 470 DSARNLPSIY 480 EGDFGCGYLK 490 ERRASGLVFC 500 ENTASVYRAL 510 FSGKKMNSNP 520 SPLVQMSVGH 530 KAQESKIRYK 540 TNEPVWEENF 550 TFFIHNPKRQ 560 ELEVEVRDEQ 570 HQCSLGNLRI 580 PLSQLLASED 590 MTMNQRFQLS 600 NSGPNSSLKM 610 KLALRVLHLE 620 KQERSPDHQH 630 SAQVKRPSVS 640 KEGRKIPVRP 650 QMSASPGTGD 660 SSTAPSSPVV 670 GGGDKPGVEE 680 RAPPAEASPQ 690 GPQDLGRSSS 700 SLQASGTGSP 710 SHISVKEPTP 720 SIASDISLPI 730 ATQELRQRLR 740 QLENGTTLGQ 750 SPLGQIQLTI 760 RHSSQRNKLV 770 VVVHSCRNLI 780 AFSEDGSDPY 790 VRLYLLPDKR 800 RSGRRKTHVS 810 KKTLNPVFDQ 820 SFDFSVSLPE 830 AQRRTLDVAV 840 KNSGGFLSKD 850 KGLLGKVLVG 860 LASEELAKGW TQW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Biological Process GO:0006869 lipid transport
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0031210 phosphatidylcholine binding
Molecular Function GO:0008429 phosphatidylethanolamine binding
Molecular Function GO:0035091 phosphatidylinositol binding
Biological Process GO:0061817 endoplasmic reticulum-plasma membrane tethering

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.