Search Results
Overview
| Uniprot ID | A0A5G2RLB6 |
|---|---|
| Protein Name | Cytosolic Fe-S cluster assembly factor NUBP1 |
| Gene Name | NUBP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | KILVLSGKGGVGKST |
| 285 | KEISFCHKVKLPIIG |
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure
Protein Sequence
10
MCFCCDTKEI
20
PTKVLGIDLC
30
SSILKGTETP
40
QAPDHRICGT
50
HALSLRFISR
60
SWRIRLGASR
70
RKYATAVSGD
80
RRGVQSSRME
90
EVPHDCPGTG
100
SAQAGRGASC
110
QGCPNQRLCA
120
SGAGAAPDPA
130
IEEIKEKMKT
140
VKHKILVLSG
150
KGGVGKSTFS
160
AHLAHGLAED
170
ENTQVALLDI
180
DICGPSIPKI
190
MGLEGEQFLE
200
DNLGVMSVGF
210
LLSSPDDAVI
220
WRGPKKNGMI
230
KQFLRDVDWG
240
ELDYLIVDTP
250
PGTSDEHLSA
260
VQYLAGAHID
270
GAVLITTPQE
280
VSLQDVRKEI
290
SFCHKVKLPI
300
IGVVENMSSF
310
LCPRCQKESQ
320
IFPPTTGGAE
330
VMCQDLKIPL
340
LGKVPLDPRI
350
AKSCDKGQSF
360
LVEAPDSPAT
370
LAYRSIIQRI
380
REFCDLRPPE
GANHVAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140663 | ATP-dependent FeS chaperone activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.