Overview
| Uniprot ID | A0A5G2RLE0 |
|---|
| Protein Name | RNA 3'-terminal phosphate cyclase |
|---|
| Gene Name | RTCA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 204 |
TDRGSVTKIYGRAFV |
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury
Protein Sequence
10
MAGPRVEVDG
20
GIMEGGGQIL
30
RVSTALSCLL
40
GLPLRVQKIR
50
AGRSTPGLSS
60
VGWKSKIRVL
70
VRPQHLSGLE
80
MVRDLCDGQL
90
EGAEIGSTEI
100
MFTPEKIKGG
110
THTADTKTAG
120
SVCLLMQVSM
130
PCVLFAASPS
140
ELRLKGGTNA
150
EMAPQIDYTA
160
MVFKPIVEKF
170
GFTFNCDIKM
180
RGYYPKGGGE
190
VIVRMSPVKQ
200
LNPINLTDRG
210
SVTKIYGRAF
220
VAGVLPFKVA
230
KDMAAAAVRC
240
IRKEIRDLYV
250
NIQPVQEPKD
260
QAFGNGSGII
270
IIAETSTGCL
280
FAGSSLGKRG
290
VNADKVGIEA
300
AEVLLANLRH
310
GGAVDEYLQD
320
QLIIFMALAS
330
GISRIKTGPV
340
TLHTQTAIHF
350
AEQLAKAKFT
360
VKKSEDEEDA
370
SKDTYIIECQ
GIGMTNPNL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0003963 |
RNA-3'-phosphate cyclase activity |
| Biological Process |
GO:1905592 |
negative regulation of optical nerve axon regeneration |
| Biological Process |
GO:0006396 |
RNA processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.