Search Results

Overview

Uniprot ID	A0A5G2RNL7
Protein Name	Thimet oligopeptidase
Gene Name	THOP1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
125	PHYFPLLKKCHVPET
135	HVPETRRKVEEAFNC
145	EAFNCRCKEENCAIL
302	VRDAASGKVIGKFYL
59	LPKETQEKIKSIKKK

Function

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 MLPQPLRATA 20 HVPGMQRLLV 30 WLEKVQKDSL 40 RPEAARYLER 50 LIKLGRRNGL 60 HLPKETQEKI 70 KSIKKKLSLL 80 CIDFNKNLNE 90 DTTFLPFTRE 100 ELGGLPEDFL 110 NSLEKTEDEK 120 LKVTLKYPHY 130 FPLLKKCHVP 140 ETRRKVEEAF 150 NCRCKEENCA 160 ILRELVRLRA 170 QKSSLLGFST 180 HADYVLEMNM 190 AKTSQVVATF 200 LDELAQKLKP 210 LGEQERAVIL 220 ELKKAECTKR 230 GLDFDGRINA 240 WDMRYYMNQV 250 EETRYRVDQN 260 LLKEYFPMQV 270 VTRGLLGIYQ 280 ELLGLTFHLE 290 EGAAVWHEDV 300 MLYSVRDAAS 310 GKVIGKFYLD 320 LYPREGKYGH 330 AACFGLQPGC 340 LRQDGSRQIA 350 IAAMVANFTK 360 PTPDAPSLLQ 370 HDEVETYFHE 380 FGHVMHQLCS 390 QAEFAMFSGT 400 HVERDFVEAP 410 SQMLENWVWE 420 AEPLLRMSQH 430 YRTGSAIPQE 440 LLEKLIKSRQ 450 ANTGLFNLRQ 460 IVLAKVDQAL 470 HTQTAADPAE 480 EYARLCQEIL 490 GVPATPGSHT 500 PSQAHFRGQG 510 KRFIVMYEGV 520 WEEEFDLWPF 530 LLWFLGWSLH 540 LGAVGMDYRS 550 CILRPGGSED 560 ASVMLKLFLG 570 RDPKQDAFLL 580 SKGLQVEGCE PPAS

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.