Search Results

Overview

Uniprot IDA0A5K1U2U1
Protein NameElongation factor-like GTPase 1
Gene NameEFL1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1003 RVYAVLSKREGRVLQ
253 FAKIYSQKTGIRKEV
450 ARRRHAEKLAAAQGQ
511 GVARRGKKIFVLGPK

Function

GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export

Protein Sequence

10 MVLNSLDKMI 20 QLQKNTANIR 30 NICVLAHVDH 40 GKTTLADCLI 50 SSNGIISSRL 60 AGKLSHSRLP 70 EKEFLYTCTT 80 ENVFSHFLSD 90 DEEYLINLID 100 SPGHVDFSSE 110 VSTAVRICDG 120 CIIVVDAVEG 130 VCPQTQAVLR 140 QAWLENIRPV 150 LVINKIDRLI 160 VELKFTPQEA 170 YSHLKNILEQ 180 INALTGTLFT 190 SKVLEERAER 200 VTESQVNPHS 210 EQGEQVYDWS 220 TGLEDTDDSH 230 LYFSPDQGNV 240 VFTSAIDGWG 250 FGIEHFAKIY 260 SQKTGIRKEV 270 LLKTLWGDYY 280 INMKAKKIMK 290 VDQAKGKKPL 300 FVQLILGNIW 310 SLYDAVLKKD 320 KEKIDKIVTS 330 LGLKIGAREA 340 RHSDPKVQIN 350 AICSQWLPIS 360 QAVLAMVCQK 370 LPSPLDITAE 380 RVEKLMCAGS 390 QTFDSLPPET 400 QALKAAFMKC 410 GSEDTAPVII 420 FVSKMFAVDA 430 KALPQNKPRP 440 LTPEEIAERR 450 ERARRRHAEK 460 LAAAQGQAPV 470 EPTQDGSALE 480 ASPKEEEPKG 490 DEQQVLQEGN 500 DQESFIAFAR 510 VFSGVARRGK 520 KIFVLGPKYS 530 PLEFLQRVPL 540 GFSAPLDGLP 550 PVPHMACCTL 560 ENLYLLMGRE 570 LEDLEEVPPG 580 NVLGIGGLQD 590 FVLKSATLCT 600 LPSCPPFIPL 610 NFEATPIVRV 620 AVEPKHPSEM 630 PQLVKGMKLL 640 NQADPCVQIL 650 IQETGEHVLV 660 TAGEVHLQRC 670 LDDLKERFAK 680 IQISVSEPII 690 PFRETITKPP 700 KVDMVNEEIG 710 KQQKVAVIHQ 720 TKEDQSKIPE 730 GIQVDSDGLV 740 TITTPNKLAT 750 LCVRAMPLPE 760 EVTQILEENS 770 DLIRSMEQLT 780 SSLNEGKNTQ 790 VIHQKTQEKI 800 GEFKGRLEQH 810 LTGRKWRNTV 820 DQIWSFGPRK 830 CGPNILVNKS 840 EDFQNSVWTG 850 PDGKASQEAN 860 RYRDLGNSIV 870 SGFQLATLSG 880 PMCEEPLMGV 890 CFVLEKWDLS 900 KFEEQTASDK 910 QNQKQSDLVD 920 AGQGEGETSS 930 AGDENQEVHN 940 GCSEPFEKRP 950 SQKGESSLTD 960 CYGPFSGQLI 970 ATMKEACRYA 980 LQVKPQRLMA 990 AMYTCDIMAT 1000 SDVLGRVYAV 1010 LSKREGRVLQ 1020 EEMKEGTDMF 1030 IIKAVLPVAE 1040 SFGFADEIRK 1050 RTSGLASPQL 1060 VFSHWEIIPS 1070 DPFWVPTTEE 1080 EYLHFGEKAD 1090 SENQARKYMN 1100 AVRKRKGLYV 1110 EEKIVEHAEK QRTLSKNK

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0042256 cytosolic ribosome assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.