Search Results
Overview
| Uniprot ID | A0A5K1UAD0 |
|---|---|
| Protein Name | Glia-derived nexin |
| Gene Name | SERPINE2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 202 | RFQPENTKKRTFVAA |
| 304 | AVAQTDLKEPLKVLG |
| 325 | PSKANFAKITRSENL |
| 342 | SHILQKAKIEVSEDG |
| 96 | KVLKKINKAIVSKKN |
Function
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin
Protein Sequence
10
MNWHFPFFLV
20
ATVTLPSVCS
30
QFNPLSLEEL
40
GSDTGIQVFN
50
QIVKSRPHDN
60
IVISPHGIAS
70
LGMLQLGADG
80
RTKKQLTTVM
90
RYGVNGVGKV
100
LKKINKAIVS
110
KKNKDIVTVA
120
NAVFVKNGFK
130
MEVPFVTRNK
140
DVFQCEVRNA
150
DFEDPASACD
160
SINLWVRNET
170
RGMIDSLLSP
180
DLLDSVLTRL
190
VLVNAVYFKG
200
LWKSRFQPEN
210
TKKRTFVAAD
220
GKSYQVPMLA
230
QLSVFRCGST
240
STPSDLWYNF
250
IELPYHGESI
260
SMLIALPTES
270
STPLSAIIPH
280
ISTKTIDSWM
290
STMVPKRVQV
300
ILPKFTAVAQ
310
TDLKEPLKVL
320
GVTEMFDPSK
330
ANFAKITRSE
340
NLHVSHILQK
350
AKIEVSEDGT
360
KASAATTAIL
370
IARSSPPWFI
380
VDRPFLFFIR
390
HNPTGAVLFM
GQINNPEE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0010757 | negative regulation of plasminogen activation |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0031091 | platelet alpha granule |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0090331 | negative regulation of platelet aggregation |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0048711 | positive regulation of astrocyte differentiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.