Overview
| Uniprot ID | A0A5K1UFV9 |
|---|
| Protein Name | - |
|---|
| Gene Name | COPS7A |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 98 |
SVVTLAAKVKCIPYA |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
RWKKKLPGSG
20
PRSLTQSTTR
30
QSAGAHGPWA
40
ASLREGAEPR
50
GRIARLAESD
60
FASTFRLLTV
70
FAYGTYADYL
80
AEARNLPPLT
90
EAQKNKLRHL
100
SVVTLAAKVK
110
CIPYAVLLEA
120
LALRNVRQLE
130
DLVIEAVYAD
140
VLRGSLDQRN
150
QRLEVDYSIG
160
RDIQRQDLSA
170
IARTLQEWCV
180
GCEVVLSGIE
190
EQVSRANQHK
200
EQQLGLKQQI
210
ESEVANLKKT
220
IKVTTAAAAA
230
ATSQDPEQHL
240
TELREPAPGT
250
NQRQPSKKAS
260
KGKGLRGSAK
IWSKSN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Biological Process |
GO:0010387 |
COP9 signalosome assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.