Overview
| Uniprot ID | A0A5K1ULP5 |
|---|
| Protein Name | COP9 signalosome complex subunit 2 |
|---|
| Gene Name | COPS2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 189 |
DDGEDDLKKGTQLLE |
| 215 |
QKNNKKLKALYEQSL |
| 93 |
PEMMNRYKQLLTYIR |
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1
Protein Sequence
10
MSDMEDDFMC
20
DDEEDYDLEY
30
SEDSNSEPNV
40
DLENQYYNSK
50
ALKEDDPKAA
60
LSSFQKVLEL
70
EGEKGEWGFK
80
ALKQMIKINF
90
KLTNFPEMMN
100
RYKQLLTYIR
110
SAVTRNYSEK
120
SINSILDYIS
130
TSKQMDLLQE
140
FYETTLEALK
150
DAKNDRLWFK
160
TNTKLGKLYL
170
EREEYGKLQK
180
ILRQLHQSCQ
190
TDDGEDDLKK
200
GTQLLEIYAL
210
EIQMYTAQKN
220
NKKLKALYEQ
230
SLHIKSAIPH
240
PLIMGVIREC
250
GGKMHLREGE
260
FEKAHTDFFE
270
AFKNYDESGS
280
PRRTTCLKYL
290
VLANMLMKSG
300
INPFDSQEAK
310
PYKNDPEILA
320
MTNLVSAYQN
330
NDITEFEKIL
340
KTNHSNIMDD
350
PFIREHIEEL
360
LRNIRTQVLI
370
KLIKPYTRIH
380
IPFISKCILD
390
NTIHGRIDQV
400
NQLLELDHQK
410
RGGARYTALD
420
KWTNQLNSLN
QAVVSKLA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0045171 |
intercellular bridge |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.