Search Results
Overview
| Uniprot ID | A0A5K1UVT7 |
|---|---|
| Protein Name | Mitogen-activated protein kinase |
| Gene Name | MAPK1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 309 | LSLPHKNKVPWNRLF |
| 381 | DLPKEKLKELIFEET |
| 92 | KVRVAIKKISPFEHQ |
Function
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity
Protein Sequence
10
MQISLSVSVT
20
LPASVVGRAA
30
AAEHRAQCGG
40
GGGGPAANMA
50
AAAAGAGPEM
60
VRGQVFDVGP
70
RYTNLSYIGE
80
GAYGMVCSAY
90
DNVNKVRVAI
100
KKISPFEHQT
110
YCQRTLREIK
120
ILLRFRHENI
130
IGINDIIRAP
140
TIEQMKDVYI
150
VQDLMETDLY
160
KLLKTQHLSN
170
DHICYFLYQI
180
LRGLKYIHSA
190
NVLHRDLKPS
200
NLLLNTTCDL
210
KICDFGLARV
220
ADPDHDHTGF
230
LTEYVATRWY
240
RAPEIMLNSK
250
GYTKSIDIWS
260
VGCILAEMLS
270
NRPIFPGKHY
280
LDQLNHILGI
290
LGSPSQEDLN
300
CIINLKARNY
310
LLSLPHKNKV
320
PWNRLFPNAD
330
SKALDLLDKM
340
LTFNPHKRIE
350
VEQALAHPYL
360
EQYYDPSDEP
370
IAEAPFKFDM
380
ELDDLPKEKL
390
KELIFEETAR
FQPGYRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004707 | MAP kinase activity |
| Biological Process | GO:0006915 | apoptotic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.