Overview
| Uniprot ID | A0A5K1VDV6 |
|---|
| Protein Name | Actin-related protein 2/3 complex subunit 4 |
|---|
| Gene Name | TTLL3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 37 |
QVVERHNKPEVEVRS |
| 46 |
EVEVRSSKELLLQPV |
| 62 |
ISRNEKEKVLIEGSI |
| 79 |
VRVSIAVKQADEIEK |
| 86 |
KQADEIEKILCHKFM |
| 91 |
IEKILCHKFMRFMMM |
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
MGLTATLRPY
20
LSAVRATLQA
30
ALCLENFSSQ
40
VVERHNKPEV
50
EVRSSKELLL
60
QPVTISRNEK
70
EKVLIEGSIN
80
SVRVSIAVKQ
90
ADEIEKILCH
100
KFMRFMMMRA
110
ENFFILRRKP
120
VEGYDISFLI
130
TNFHTEQMYK
140
HKLVDFVIHF
150
MEEIDKEISE
160
MKLSVNARAR
170
IVAEEFLKNV
180
LLSFGEDSPR
190
RLNTWAGSEM
200
PRSTWRELSR
SERVAGRGF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030041 |
actin filament polymerization |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.