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Overview

Uniprot IDA0A5K1VLI8
Protein NameGeneral transcription factor II-I
Gene NameGTF2I
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
130 CYGKALGKSTVVPVP
219 GGSCGPIKVKTEPTE
285 SPPTKRPKSNEPPQP
312 VREFNFEKWNARITD
337 RKYAQAIKAKGPVTI
385 LERILLAKERIRFVI
394 RIRFVIKKHELLNST
415 DKPASGVKEEWYARI
436 VDQLFCKKFAEALGS
485 YGIPRLEKIIQVGNR
532 VRITKLRKQVEEIFN
623 MASKINTKALQSPKR
782 KESTSSSKSPPRKIN

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSTLP 20 VEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKSTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVVV 160 QGLPEGVAFK 170 HPENYDLATL 180 KWILENKAGI 190 SFIIKRPFLE 200 PKKHLGGRVM 210 VTDTERSMLS 220 PGGSCGPIKV 230 KTEPTEDSGI 240 SLEMAAVTVK 250 EESEDPDYYQ 260 YNIQGSHHSS 270 EGNEGTEMEV 280 PAEDDDYSPP 290 TKRPKSNEPP 300 QPPVTEPANA 310 GKRKVREFNF 320 EKWNARITDL 330 RKQVEELFER 340 KYAQAIKAKG 350 PVTIPYPLFQ 360 SHVEDLYVEG 370 LPEGIPFRRP 380 STYGIPRLER 390 ILLAKERIRF 400 VIKKHELLNS 410 TREDLQLDKP 420 ASGVKEEWYA 430 RITKLRKMVD 440 QLFCKKFAEA 450 LGSTEAKAVP 460 YQKFEAHPND 470 LYVEGLPENI 480 PFRSPSWYGI 490 PRLEKIIQVG 500 NRIKFVIKRP 510 ELLTHSTTEV 520 TQPRTNTPVK 530 EDWNVRITKL 540 RKQVEEIFNL 550 KFAQALGLTE 560 AVKVPYPVFE 570 SNPEFLYVEG 580 LPEGIPFRSP 590 TWFGIPRLER 600 IVRGSNKIKF 610 VVKKPELVIS 620 YLPPGMASKI 630 NTKALQSPKR 640 PRSPGSNSKV 650 PEIEVTVEGP 660 NNSNPQTSAV 670 RTPTQTNGSN 680 VPFKPRGREF 690 SFEAWNAKIT 700 DLKQKVENLF 710 NEKCGEALGL 720 KQAVKVPFAL 730 FESFPEDFYV 740 EGLPEGVPFR 750 RPSTFGIPRL 760 EKILRNKAKI 770 KFIIKKPEMF 780 ETAIKESTSS 790 SKSPPRKINS 800 SPNVNTTASG 810 VEDLNIIQVT 820 IPDDDNERLS 830 KVEKARQLRE 840 QVNDLFSRKF 850 GEAIGMGFPV 860 KVPYRKITIN 870 PGCVVVDGMP 880 PGVSFKAPSY 890 LEISSMRRIL 900 DSAEFIKFTV 910 IRPFPGLVIN 920 NQLVDQNESE 930 GPVIQESSEP 940 SQLEVPATEE 950 IKETDGNSQI KQEPDPTW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.