Search Results
Overview
| Uniprot ID | A0A5K1VSC0 |
|---|---|
| Protein Name | Wiskott-Aldrich syndrome protein family member |
| Gene Name | WASF2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 78 | RVDRLQVKVTQLDPK |
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex
Protein Sequence
10
MPLVTRNIEP
20
RHLCRQTLPS
30
VRSELECMTN
40
ITLANVIRQL
50
GSLSKYAEDI
60
FGELFTQANT
70
FASRVSSLAE
80
RVDRLQVKVT
90
QLDPKEEEVS
100
LQGINTRKAF
110
RSSTVQDQKL
120
FDRNSLPIPV
130
LETYNTCDTP
140
PPLNNLTPYR
150
DDGKEALKFY
160
TDPSYFFDLW
170
KEKMLQDTKD
180
IMKEKRKHRK
190
EKKDNPNRGN
200
VNPRKIKTRK
210
EEWEKMKMGQ
220
EFVESKEKLG
230
PSGYPPTLVY
240
QNGSVGSVEN
250
VDASSYPPPP
260
QSDSTSPPSP
270
SFSEDSLPPP
280
PAEFSYPADS
290
NQRGSGLAGP
300
KRSSVVSPSH
310
PPPAPPLGSP
320
PGPKPGFAPP
330
PAPPPPPPMM
340
STPPPPPPGG
350
FGSSGTPPPP
360
SPPSFPPHPD
370
FAAPPPPPPP
380
PAADYSTLPP
390
PPLSQPAGGA
400
PPPPPPPPPP
410
GPPPPPFSGT
420
DGQPAAPPPL
430
SDTTKPKSSL
440
PPVSDARSDL
450
LSAIRQGFQL
460
RRVEEQREQE
470
KRDVVGNDVA
480
TILSRRIAVE
490
YSDSEDDSSE
FDEDEWSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0031209 | SCAR complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0071933 | Arp2/3 complex binding |
| Molecular Function | GO:0034237 | protein kinase A regulatory subunit binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0098974 | postsynaptic actin cytoskeleton organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.