Search Results
Overview
| Uniprot ID | A0A5S6FV10 |
|---|---|
| Protein Name | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| Gene Name | DLST |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 182 | SKPVSAVKPTAAPPV |
| 246 | QDMRARHKEAFLKKH |
| 332 | TISELGEKARKNELA |
| 419 | VTFLRKIKAAVEDPR |
| 45 | FRTTAVCKDDVITVK |
Function
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A
Protein Sequence
10
MGRFYPCSVV
20
PPSSSSWGQP
30
GLQVLSISNS
40
SVLNVRFFRT
50
TAVCKDDVIT
60
VKTPAFAESV
70
TEGDVRWEKA
80
VGDTVAEDEV
90
VCEIETDKTS
100
VQVPSPANGV
110
IEALLVPDGG
120
KVEGGTPLFT
130
LRKTGAAPAK
140
AKPAEAPAAA
150
APKAEPAVSA
160
VPPPPAASIP
170
TQMPPVPSPP
180
QPLTSKPVSA
190
VKPTAAPPVA
200
EPGAVKGLRA
210
EHREKMNRMR
220
QRIAQRLKEA
230
QNTCAMLTTF
240
NEIDMSNIQD
250
MRARHKEAFL
260
KKHNLKLGFM
270
SAFVKASAFA
280
LQEQPVVNAV
290
IDDTTKEVVY
300
RDYIDISVAV
310
ATPRGLVVPV
320
IRNVETMNYA
330
DIERTISELG
340
EKARKNELAI
350
EDMDGGTFTI
360
SNGGVFGSLF
370
GTPIINPPQS
380
AILGMHAIVD
390
RPVAVGGKVE
400
IRPMMYVALT
410
YDHRLIDGRE
420
AVTFLRKIKA
430
AVEDPRVLLL
DL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0045252 | oxoglutarate dehydrogenase complex |
| Molecular Function | GO:0004149 | dihydrolipoyllysine-residue succinyltransferase activity |
| Biological Process | GO:0033512 | L-lysine catabolic process to acetyl-CoA via L-saccharopine |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.